DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and sxc

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_523620.1	Gene:	sxc / 35486	FlyBaseID:	FBgn0261403	Length:	1059	Species:	Drosophila melanogaster

Alignment Length:	439	Identity:	92/439 - (20%)
Similarity:	160/439 - (36%)	Gaps:	113/439 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GLIDREEGNHIEALRHLQKSAELNPRNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEI 138
            |.:...:|....|:.|.:|:..|:|..::.|..:|..|.....|.:|:..:..|...|  .::.:
  Fly   227 GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALNLS--PNNAV 289

  Fly   139 YHYLGELLYRAATTQSQKDVASQQQDEARTYFE-----LAVQSGRKL--------ESYVRLAELY 190
            .|  |.|                    |..|:|     ||:.:.|:.        ::|..||...
  Fly   290 VH--GNL--------------------ACVYYEQGLIDLAIDTYRRAIELQPNFPDAYCNLANAL 332

  Fly   191 RKDKQYQKAIEILENCLHLTPENSEVL-------------IEISVLYLKINET----QKAHDRLA 238
            ::..|.::|.:.....|.|...:::.|             .|.:.||||..|.    ..||..||
  Fly   333 KEKGQVKEAEDCYNTALRLCSNHADSLNNLANIKREQGYIEEATRLYLKALEVFPDFAAAHSNLA 397

  Fly   239 EVVSIERKCSPKGLLAFGAILQSRNDIDGALSKYSQIANAEPEIAELWNNIGLCFFKKQKFIVAI 303
                              ::||.:..:..||..|.:....:|..|:.::|:|....:.|....|:
  Fly   398 ------------------SVLQQQGKLKEALMHYKEAIRIQPTFADAYSNMGNTLKELQDVSGAL 444

  Fly   304 SSLRKSVWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAECYMLLGLCLRKLDDME 368
            ....:::.::|...:|..||:.|:..|.....|..:...|:.|:.|..:.|..|..||:.:.|..
  Fly   445 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIQSYRTALKLKPDFPDAYCNLAHCLQIVCDWT 509

  Fly   369 NAFVALERASSMATGQQGAGRNP------------------LVVLNFALFCYETGRLALSTEQYN 415
            :..:.:::..|:.|.|....|.|                  .:....|..|.|...: |..:.||
  Fly   510 DYDIRMKKLVSIVTEQLEKNRLPSVHPHHSMLYPLTHDCRKAIAARHANLCLEKVHV-LHKKPYN 573

  Fly   416 RFMSQAQDLLLPTEYKFQATKLKSLLRISNQGNGILLDSADMGESDLGH 464
             |:.:     |||         |..|||     |.|  |:|.|.....|
  Fly   574 -FLKK-----LPT---------KGRLRI-----GYL--SSDFGNHPTSH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	12/52 (23%)
		TPR repeat	68..95	CDD:276809	5/20 (25%)
		TPR_12	97..175	CDD:290160	16/82 (20%)
		TPR repeat	100..130	CDD:276809	6/29 (21%)
		TPR repeat	136..175	CDD:276809	8/43 (19%)
		TPR repeat	179..209	CDD:276809	6/37 (16%)
		TPR_19	190..254	CDD:291240	15/80 (19%)
		TPR repeat	214..242	CDD:276809	11/44 (25%)
		TPR repeat	249..277	CDD:276809	5/27 (19%)
		TPR_11	283..348	CDD:290150	14/64 (22%)
		TPR repeat	283..311	CDD:276809	5/27 (19%)
		TPR repeat	316..346	CDD:276809	7/29 (24%)
		TPR repeat	351..377	CDD:276809	5/25 (20%)
sxc	NP_523620.1	TPR repeat	53..78	CDD:276809
		TPR_11	86..149	CDD:290150
		TPR repeat	86..112	CDD:276809
		TPR_11	118..183	CDD:290150
		TPR_1	118..151	CDD:278916
		TPR repeat	118..146	CDD:276809
		TPR repeat	151..181	CDD:276809
		TPR_12	182..252	CDD:290160	6/24 (25%)
		TPR_1	192..219	CDD:278916
		TPR_1	220..253	CDD:278916	7/25 (28%)
		TPR repeat	220..248	CDD:276809	5/20 (25%)
		TPR	233..490	CDD:223533	60/298 (20%)
		TPR_1	255..287	CDD:278916	7/33 (21%)
		TPR repeat	255..282	CDD:276809	6/26 (23%)
		TPR repeat	287..317	CDD:276809	9/51 (18%)
		TPR_1	288..321	CDD:278916	9/54 (17%)
		TPR_17	310..342	CDD:290167	5/31 (16%)
		TPR repeat	322..350	CDD:276809	5/27 (19%)
		TPR repeat	355..385	CDD:276809	6/29 (21%)
		TPR_10	356..>385	CDD:290111	6/28 (21%)
		TPR_1	390..423	CDD:278916	10/50 (20%)
		TPR repeat	390..418	CDD:276809	9/45 (20%)
		TPR repeat	423..453	CDD:276809	5/29 (17%)
		TPR_1	424..455	CDD:278916	5/30 (17%)
		TPR_1	458..491	CDD:278916	8/32 (25%)
		TPR repeat	458..486	CDD:276809	7/27 (26%)
		Glyco_transf_41	584..1044	CDD:290556	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467062
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840