DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and CG14921

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_609491.1	Gene:	CG14921 / 34547	FlyBaseID:	FBgn0032345	Length:	240	Species:	Drosophila melanogaster

Alignment Length:	206	Identity:	43/206 - (20%)
Similarity:	74/206 - (35%)	Gaps:	71/206 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RLIERELNRHLNPEYLYFVQGLIDREEGNHIEALRHLQKSAELNPRNIETYKEIGRTLYIMGRFS 118
            ||:.|:.:..|.|:||.|....|..|        |||.:..:........:|...|.:.:    .
  Fly    19 RLVTRKPDVVLLPQYLKFNNPPIFFE--------RHLAQEIDEMASFCRIFKNEARIVLV----K 71

  Fly   119 QALGVFREAEQRSSRQDHEIYHYLGELLYRAATTQSQKDVASQQQDEARTYFELAVQSGRK---- 179
            :..|::.|..|:               |.:.|..|.:.::|           :|.|:..:|
  Fly    72 KEKGLWPEMFQK---------------LDKEALMQKRLEIA-----------DLIVERNKKRDEK 110

  Fly   180 -LESY--VRLAELYRKDKQYQKAIEILENCLHLTPENSEVLIEISVLYLKINETQKAHDRLAEVV 241
             ||.|  .|.||:   .|:.|:..::.|                     ::.:.|:...|.|.||
  Fly   111 ALERYDNKRRAEI---QKEIQRETDMRE---------------------RVKQFQENSVREALVV 151

  Fly   242 SI--ERKCSPK 250
            .:  |.|.:||
  Fly   152 DVRKEAKATPK 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	13/63 (21%)
		TPR repeat	68..95	CDD:276809	8/26 (31%)
		TPR_12	97..175	CDD:290160	10/77 (13%)
		TPR repeat	100..130	CDD:276809	4/29 (14%)
		TPR repeat	136..175	CDD:276809	5/38 (13%)
		TPR repeat	179..209	CDD:276809	10/36 (28%)
		TPR_19	190..254	CDD:291240	12/63 (19%)
		TPR repeat	214..242	CDD:276809	4/27 (15%)
		TPR repeat	249..277	CDD:276809	2/2 (100%)
		TPR_11	283..348	CDD:290150
		TPR repeat	283..311	CDD:276809
		TPR repeat	316..346	CDD:276809
		TPR repeat	351..377	CDD:276809
CG14921	NP_609491.1	p23_DYX1C1_like	4..81	CDD:107226	17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900