DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BBS4 and IFIT3

DIOPT Version :9

Sequence 1:NP_610636.1 Gene:BBS4 / 36167 FlyBaseID:FBgn0033578 Length:486 Species:Drosophila melanogaster
Sequence 2:NP_001026853.1 Gene:IFIT3 / 3437 HGNCID:5411 Length:490 Species:Homo sapiens


Alignment Length:525 Identity:114/525 - (21%)
Similarity:204/525 - (38%) Gaps:119/525 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 TLEVVRPAPKMPSDANIDWLLHIYFTRREFTRCRRLIERELNR--HLNPEY---LYFVQGLIDRE 79
            :||.:.|..|    .:..|.|.     :|.:..|.|.:|..|:  .||.|:   :|.:...|...
Human     8 SLEKILPQLK----CHFTWNLF-----KEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHL 63

  Fly    80 EGNHIEALRHLQKSAEL---------NPRNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQD 135
            :||:..||..|:::.||         ..|::.|:.......|.:||.|.|.....:.:|...:..
Human    64 DGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFS 128

  Fly   136 HEIYHYLGELLYRAATTQSQKDVASQQQDEARTYFELAVQ---SGRKLESYVRLAELYRKDKQYQ 197
            :.......||......||    :...:.:.|:..||.|::   :..:..|.:.:| :|..|...:
Human   129 NPYSIEYSELDCEEGWTQ----LKCGRNERAKVCFEKALEEKPNNPEFSSGLAIA-MYHLDNHPE 188

  Fly   198 K--AIEILENCLHLTPENSEVLIEISVLYLKINETQKAHDRLAEVVSIERKCSPKGLLAFGAILQ 260
            |  :.::|:..:.|:|:|..|.:.:.:...|:|:..:....:.|.:. :..|....|.:.....:
Human   189 KQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALE-KSPCQTDVLRSAAKFYR 252

  Fly   261 SRNDIDGALSKYSQIANAEPEIAELWNNIGLCFFKK---------------QKFIVAI------- 303
            .:.|:|.|:..:.::..:.|....|::.||.|:..|               ::.|.|:       
Human   253 RKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDY 317

  Fly   304 --SSLRKSVWLSPLN-YNALYNLSLIYIASEQYASAFH----------TLAAAINLRK------D 349
              .:|.|.  |:||| |:.|..    ::.:|.|.:.|:          :.....||:|      |
Human   318 SNKALEKG--LNPLNAYSDLAE----FLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSED 376

  Fly   350 NAECYMLLGLCL-RKLDDMENAFVALERASSMATGQQGAGRNPLVVLNFALFCYETGRLALSTEQ 413
            .|..:.|.||.: :|..|.|          .:....|....| |:..|...:.|..|.:      
Human   377 TAVQHGLEGLSISKKSTDKE----------EIKDQPQNVSEN-LLPQNAPNYWYLQGLI------ 424

  Fly   414 YNRFMSQAQDLLLPTEYKFQATK-----LKSLLRISNQGNG-ILLDSADM--GESDLGHNRATEL 470
                ..|..|||       ||.|     |..|||.:..|.| |.|.::::  |..::|.. |...
Human   425 ----HKQNGDLL-------QAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQG-AVSS 477

  Fly   471 LPDEL 475
            .|.||
Human   478 SPREL 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BBS4NP_610636.1 TPR_12 63..127 CDD:290160 19/75 (25%)
TPR repeat 68..95 CDD:276809 7/29 (24%)
TPR_12 97..175 CDD:290160 16/77 (21%)
TPR repeat 100..130 CDD:276809 6/29 (21%)
TPR repeat 136..175 CDD:276809 8/38 (21%)
TPR repeat 179..209 CDD:276809 6/31 (19%)
TPR_19 190..254 CDD:291240 13/65 (20%)
TPR repeat 214..242 CDD:276809 4/27 (15%)
TPR repeat 249..277 CDD:276809 4/27 (15%)
TPR_11 283..348 CDD:290150 20/99 (20%)
TPR repeat 283..311 CDD:276809 9/51 (18%)
TPR repeat 316..346 CDD:276809 6/40 (15%)
TPR repeat 351..377 CDD:276809 7/26 (27%)
IFIT3NP_001026853.1 TPR_12 51..126 CDD:290160 17/74 (23%)
TPR 1 51..84 9/32 (28%)
TPR repeat 51..79 CDD:276809 7/27 (26%)
TPR repeat 84..123 CDD:276809 7/38 (18%)
TPR 2 94..127 7/32 (22%)
TPR 3 136..169 8/36 (22%)
TPR repeat 136..164 CDD:276809 8/31 (26%)
TPR_19 150..213 CDD:291240 14/63 (22%)
TPR 4 172..206 8/34 (24%)
PRK02603 184..341 CDD:179448 31/163 (19%)
TPR repeat 206..236 CDD:276809 5/30 (17%)
TPR 5 207..240 4/33 (12%)
TPR 6 241..274 5/32 (16%)
TPR repeat 241..269 CDD:276809 4/27 (15%)
TPR 7 415..448 12/49 (24%)
TPR 8 450..481 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..490 5/17 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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