DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and ogt.1

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001017359.1	Gene:	ogt.1 / 337685	ZFINID:	ZDB-GENE-030131-9631	Length:	1062	Species:	Danio rerio

Alignment Length:	425	Identity:	88/425 - (20%)
Similarity:	163/425 - (38%)	Gaps:	66/425 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GLIDREEGNHIEALRHLQKSAELNPRNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEI 138
            |.:...:|....|:.|.:|:..|:|..::.|..:|..|.....|.:|:..:..|  .|...:|.:
Zfish   198 GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRA--LSLSPNHAV 260

  Fly   139 YHYLGELLYRAATTQSQKDVASQQQDEARTYFE-----LAVQSGRKL--------ESYVRLAELY 190
            .|  |.|                    |..|:|     ||:.:.|:.        ::|..||...
Zfish   261 VH--GNL--------------------ACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANAL 303

  Fly   191 RKDKQYQKAIEILENCLHLTPENSEVLIEISVLYLKINETQKAHDRLAEVVSIERKC---SPKGL 252
            ::.....:|.|.....|.|.|.:::.|..::       ..::....:.|.|.:.||.   .|:..
Zfish   304 KEKGNVSEAEECYNTALRLCPTHADSLNNLA-------NIKREQGNIEEAVQLYRKALEVFPEFA 361

  Fly   253 LA---FGAILQSRNDIDGALSKYSQIANAEPEIAELWNNIGLCFFKKQKFIVAISSLRKSVWLSP 314
            .|   ..::||.:..:..||..|.:.....|..|:.::|:|....:.|....|:....:::.::|
Zfish   362 AAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINP 426

  Fly   315 LNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAECYMLLGLCLRKLDDMENAFVALERASS 379
            ...:|..||:.|:..|.....|..:...|:.|:.|..:.|..|..||:.:.|..:....:::..|
Zfish   427 AFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVS 491

  Fly   380 MATGQQGAGRNPLVVLNFA-LFCYETG-RLALSTEQYNRFMSQAQDLLLPT-EYKFQATKLKSLL 441
            :...|....|.|.|..:.: |:....| |.|::....|..:.:...|..|. |:..........|
Zfish   492 IVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINALHKPAYEHPKDLKASSGRL 556

  Fly   442 RISNQGNGILLDSADMGESDLGHNRATELLPDELP 476
            |:     |.:  |:|.|      |..|..|...:|
Zfish   557 RV-----GYI--SSDFG------NHPTSHLMQSIP 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	12/52 (23%)
		TPR repeat	68..95	CDD:276809	5/20 (25%)
		TPR_12	97..175	CDD:290160	17/82 (21%)
		TPR repeat	100..130	CDD:276809	6/29 (21%)
		TPR repeat	136..175	CDD:276809	9/43 (21%)
		TPR repeat	179..209	CDD:276809	6/37 (16%)
		TPR_19	190..254	CDD:291240	11/66 (17%)
		TPR repeat	214..242	CDD:276809	2/27 (7%)
		TPR repeat	249..277	CDD:276809	7/30 (23%)
		TPR_11	283..348	CDD:290150	14/64 (22%)
		TPR repeat	283..311	CDD:276809	5/27 (19%)
		TPR repeat	316..346	CDD:276809	7/29 (24%)
		TPR repeat	351..377	CDD:276809	5/25 (20%)
ogt.1	NP_001017359.1	TPR	20..285	CDD:223533	24/110 (22%)
		TPR repeat	24..49	CDD:276809
		TPR repeat	57..83	CDD:276809
		TPR_1	89..122	CDD:278916
		TPR repeat	89..117	CDD:276809
		TPR repeat	122..152	CDD:276809
		TPR repeat	157..185	CDD:276809
		TPR_1	163..190	CDD:278916
		TPR_1	191..224	CDD:278916	7/25 (28%)
		TPR repeat	191..219	CDD:276809	5/20 (25%)
		TPR	204..461	CDD:223533	58/287 (20%)
		TPR_17	213..246	CDD:290167	9/32 (28%)
		TPR repeat	226..253	CDD:276809	6/28 (21%)
		TPR repeat	259..287	CDD:276809	9/49 (18%)
		SNAP	276..430	CDD:305195	30/160 (19%)
		TPR repeat	290..322	CDD:276937	6/31 (19%)
		TPR_1	293..326	CDD:278916	8/32 (25%)
		TPR repeat	293..321	CDD:276809	5/27 (19%)
		TPR repeat	323..358	CDD:276937	6/41 (15%)
		TPR repeat	326..356	CDD:276809	5/36 (14%)
		TPR repeat	361..389	CDD:276809	6/27 (22%)
		TPR repeat	362..402	CDD:276937	9/39 (23%)
		TPR repeat	395..423	CDD:276809	5/27 (19%)
		TPR_1	429..462	CDD:278916	8/32 (25%)
		TPR repeat	429..457	CDD:276809	7/27 (26%)
		Glyco_transf_41	556..1038	CDD:290556	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910