DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and CG31690

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	326	Identity:	68/326 - (20%)
Similarity:	121/326 - (37%)	Gaps:	90/326 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 YFVQGLIDREEGNHIEALRHLQKSAELNPRNIETYKEIGRTLYIMGRFSQ-ALGVFREAE--QRS 131
            :|..|::.:::.|...|:...:::.||.|:....|..:|.:|..:|...| |:.|.|...  :.|
  Fly   555 HFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGS 619

  Fly   132 SRQDHEIYHYLGELLYRAATTQSQKDVASQQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQY 196
            ..:|            |.|..::                        :...|::|:.|||.|.:.
  Fly   620 GVRD------------RGAHVEA------------------------RYTCYLQLSVLYRSDGRL 648

  Fly   197 QKAIEILE---NCLHLTPENSEVLIEISVLYLKINE--------TQKAH-DRLAEVVSIERKCSP 249
            |.|...|.   ..|.|.|:...     :||:|::.|        .:..| .|||..:..|:..:
  Fly   649 QDAAAALRESLKALPLLPQKQR-----AVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAA- 707

  Fly   250 KGLLAFGAILQSRN-----DIDGALSKYSQIANAEPEIAELWNNIGLCFFKKQKFIVAISSLR-K 308
              .:.:|..| :||     :.:....:..|:|..||.....:.:    |.::|:.......|| :
  Fly   708 --YVTYGQTL-ARNGSRLAEAESWFKRALQLAPLEPSSHHHYAD----FLEQQERHHEALGLRLR 765

  Fly   309 SVWLSPLNY-------------NALYNLSLIY---IASEQYASAFHTLAAAI----NLRKDNAEC 353
            :..|:|.:|             |.|....|.|   :..:..|:..|....||    .|||:...|
  Fly   766 AAALAPQDYTLQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVAC 830

  Fly   354 Y 354
            |
  Fly   831 Y 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	15/57 (26%)
		TPR repeat	68..95	CDD:276809	4/24 (17%)
		TPR_12	97..175	CDD:290160	13/80 (16%)
		TPR repeat	100..130	CDD:276809	8/32 (25%)
		TPR repeat	136..175	CDD:276809	2/38 (5%)
		TPR repeat	179..209	CDD:276809	10/32 (31%)
		TPR_19	190..254	CDD:291240	18/75 (24%)
		TPR repeat	214..242	CDD:276809	8/36 (22%)
		TPR repeat	249..277	CDD:276809	5/32 (16%)
		TPR_11	283..348	CDD:290150	16/85 (19%)
		TPR repeat	283..311	CDD:276809	4/28 (14%)
		TPR repeat	316..346	CDD:276809	9/49 (18%)
		TPR repeat	351..377	CDD:276809	2/4 (50%)
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	6/27 (22%)
		TPR repeat	518..546	CDD:276809
		TPR repeat	551..581	CDD:276809	4/25 (16%)
		TPR_1	552..584	CDD:278916	6/28 (21%)
		TPR	565..841	CDD:223533	66/316 (21%)
		TPR repeat	586..611	CDD:276809	7/24 (29%)
		TPR repeat	634..660	CDD:276809	9/25 (36%)
		TPR repeat	671..699	CDD:276809	8/27 (30%)
		TPR repeat	704..735	CDD:276809	4/34 (12%)
		TPR repeat	740..768	CDD:276809	5/31 (16%)
		TPR repeat	773..803	CDD:276809	5/29 (17%)
		TPR	808..841	CDD:197478	8/24 (33%)
		TPR repeat	808..836	CDD:276809	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830