DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BBS4 and BBS8

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_608524.1	Gene:	BBS8 / 33217	FlyBaseID:	FBgn0031255	Length:	549	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	69/376 - (18%)
Similarity:	139/376 - (36%)	Gaps:	109/376 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 EALRHLQKSAELNPRNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEIYHYLGELLYRA 149
            :|...|.:::.|||......:.:.:.|:      |.| .:.||:.:.:   |.:...:.|:
  Fly   229 DATSKLYQASRLNPTIYAERETLVKALF------QFL-YYHEADVQKA---HSLCQAVLEV---- 279

  Fly   150 ATTQSQKDVAS---------QQQ-----------DEARTYFELAVQSGRKLESYVRLAELYRKDK 194
               :.||...|         |||           ..|..:.:.::.|....::|:.|:.:|::.|
  Fly   280 ---ERQKPSGSTGCTLSWWWQQQMGRCLLALHYPRRAEPFLQQSLTSFPHPDTYLLLSRVYQRIK 341

  Fly   195 QYQKAIEILENCLHLTPENSEVLIEISVLYLKINETQKAHDRLAEVVSIERKCSPKGLLAFGAIL 259
            |.::|:.::...:...|.:....:|    ..:|::..:..:...::..:..|..|..:.:..:|.
  Fly   342 QPERALLVIGEVVDSRPFDVTYRLE----QARIHQAMEQQEDALQLYRLAAKLHPINVESLASIA 402

  Fly   260 QS---RNDIDGALSKYSQIANAEPEIAELWNNIGLC------------FFKKQKFIVAISSLRKS 309
            ..   .|:.:.||..|.:|.:...:..||:.||.||            .|::..........:..
  Fly   403 VGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQPGQKSD 467

  Fly   310 VWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAECYMLLGLCLRKLDDMENAFVAL 374
            :|         ||||.:.:.|..:           ||.|   .|   |.|||
  Fly   468 IW---------YNLSFVAVTSGDF-----------NLAK---RC---LQLCL------------- 493

  Fly   375 ERASSMATGQQGAGRNPLVVLNFALFCYETGRLALSTEQYNRFMSQAQDLL 425
                 .:..|.||..|     |.|:...::|.: |..:.|   ::.|:|::
  Fly   494 -----TSDAQNGAALN-----NLAVLAAQSGDI-LGAKSY---LNAAKDVM 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	8/41 (20%)
		TPR repeat	68..95	CDD:276809	2/9 (22%)
		TPR_12	97..175	CDD:290160	16/97 (16%)
		TPR repeat	100..130	CDD:276809	5/29 (17%)
		TPR repeat	136..175	CDD:276809	9/58 (16%)
		TPR repeat	179..209	CDD:276809	6/29 (21%)
		TPR_19	190..254	CDD:291240	9/63 (14%)
		TPR repeat	214..242	CDD:276809	2/27 (7%)
		TPR repeat	249..277	CDD:276809	7/30 (23%)
		TPR_11	283..348	CDD:290150	15/76 (20%)
		TPR repeat	283..311	CDD:276809	7/39 (18%)
		TPR repeat	316..346	CDD:276809	5/29 (17%)
		TPR repeat	351..377	CDD:276809	5/25 (20%)
BBS8	NP_608524.1	TPR repeat	299..322	CDD:276809	2/22 (9%)
		TPR repeat	327..355	CDD:276809	6/27 (22%)
		TPR_16	331..392	CDD:290168	9/64 (14%)
		TPR repeat	365..389	CDD:276809	2/27 (7%)
		Coatomer_WDAD	<378..519	CDD:281977	37/190 (19%)
		TPR_11	394..457	CDD:290150	13/62 (21%)
		TPR repeat	394..424	CDD:276809	6/29 (21%)
		TPR repeat	429..457	CDD:276809	7/27 (26%)
		TPR_11	465..526	CDD:290150	23/113 (20%)
		TPR repeat	466..493	CDD:276809	12/52 (23%)
		TPR repeat	500..526	CDD:276809	8/34 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840