DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and Spag1

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001012116.1	Gene:	Spag1 / 315033	RGDID:	1310702	Length:	893	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	91/453 - (20%)
Similarity:	159/453 - (35%)	Gaps:	117/453 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GLIDREEGNHIEALRHLQKSAELNPRNIETYKEIGRTLYIMGRFSQAL----GVFREAEQRSSRQ 134
            |.....:.:.:|..|......:|..|        |..|:..|:|::|.    |...:.|...|..
  Rat   410 GTASTSDNHDLEERRAADSPGDLKSR--------GNELFRGGQFAEAAVQYSGAIAQLEPTGSEN 466

  Fly   135 DHEIYHYLGELLY--RAATTQSQKDVASQQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQYQ 197
            ..|:     .:||  |||....:.:.....||..|. .||...:.:.|   :|.|..|...:||:
  Rat   467 ADEL-----SILYSNRAACYLKEGNCRGCIQDCDRA-LELQPFAVKPL---LRRAMAYETLEQYR 522

  Fly   198 KA----IEILE-NC-LHLTPEN----SEVLIEISVLYLKINETQKAHDRLAEVVSI--------- 243
            .|    |.:|: :| :.|..::    :.:|.|:        :..|..:||..:.::
  Rat   523 SAYVDYITVLKIDCRIQLASDSVNRITRILTEL--------DGPKWRERLPPIPAVPASEPLRVW 579

  Fly   244 ------------ERKCSP--------KGLLAFGAILQSRNDIDGALSKYSQIANAEPEIAELWNN 288
                        ...|:|        :.|...|..|....:...|:|||::......:...::.|
  Rat   580 HPAAETPDQDPCPNSCTPTITDEKMFQALKEEGNQLVKDKNYKDAISKYNECLKINSKACAIYTN 644

  Fly   289 IGLCFFKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAEC 353
            ..||:.|..:|..|.....|::.:...|..|.|.|.|.....|.........:..:.|..|::|.
  Rat   645 RALCYLKLGQFEEAKLDCDKALQIDSKNVKASYRLELAQKGLENCRERVADPSQVVLLSPDSSEA 709

  Fly   354 YMLLG----------------LCLRKLDDMENAFVALERASSMATGQQG-----AG-------RN 390
            ...|.                :.::::||..:.  ..||.:..:..::|     ||       ||
  Rat   710 ARHLDTKNDTAPPSRERERRRIEIQEVDDSSDE--EPERPAEASAVEEGWSAERAGKIEVCKPRN 772

  Fly   391 PLVVLNFALFCYETGRLALSTEQYNRFMSQAQDLLLPTEYKFQATK-LKSLLRISNQGNGILL 452
                      .||.|:: |||....:.......||:     |.|.: |..||....:|:.:||
  Rat   773 ----------AYEFGQV-LSTISARKDEEACAQLLV-----FTAPQDLPVLLSNKLEGDMLLL 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	11/56 (20%)
		TPR repeat	68..95	CDD:276809	3/20 (15%)
		TPR_12	97..175	CDD:290160	20/83 (24%)
		TPR repeat	100..130	CDD:276809	7/33 (21%)
		TPR repeat	136..175	CDD:276809	11/40 (28%)
		TPR repeat	179..209	CDD:276809	10/35 (29%)
		TPR_19	190..254	CDD:291240	16/102 (16%)
		TPR repeat	214..242	CDD:276809	5/27 (19%)
		TPR repeat	249..277	CDD:276809	8/35 (23%)
		TPR_11	283..348	CDD:290150	14/64 (22%)
		TPR repeat	283..311	CDD:276809	7/27 (26%)
		TPR repeat	316..346	CDD:276809	6/29 (21%)
		TPR repeat	351..377	CDD:276809	5/41 (12%)
Spag1	NP_001012116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..155
		3a0801s09	141..>303	CDD:273380
		TPR 1	213..246
		TPR repeat	217..241	CDD:276809
		TPR repeat	246..275	CDD:276809
		TPR 2	247..279
		TPR 3	280..313
		TPR repeat	280..308	CDD:276809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..437		5/34 (15%)
		TPR 4	429..463		9/41 (22%)
		3a0801s09	<432..>569	CDD:273380	37/161 (23%)
		TPR repeat	432..458	CDD:276809	8/33 (24%)
		TPR repeat	466..500	CDD:276809	9/39 (23%)
		TPR 5	471..504		10/33 (30%)
		TPR repeat	505..533	CDD:276809	8/30 (27%)
		TPR 6	506..538		10/34 (29%)
		3a0801s09	569..>695	CDD:273380	22/125 (18%)
		TPR 7	605..638		7/32 (22%)
		TPR repeat	606..633	CDD:276809	7/26 (27%)
		TPR repeat	638..668	CDD:276809	7/29 (24%)
		TPR 8	639..672		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..756		7/53 (13%)
		RPAP3_C	769..858	CDD:404718	18/67 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900