DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BBS4 and IFIT5

DIOPT Version :9

Sequence 1:NP_610636.1 Gene:BBS4 / 36167 FlyBaseID:FBgn0033578 Length:486 Species:Drosophila melanogaster
Sequence 2:NP_036552.1 Gene:IFIT5 / 24138 HGNCID:13328 Length:482 Species:Homo sapiens


Alignment Length:362 Identity:72/362 - (19%)
Similarity:128/362 - (35%) Gaps:102/362 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 SDANIDWLLHIYFTRREFTRCRRLIEREL-----NRHLNPEYLYFVQGLIDREEGNHIE--ALRH 89
            :|....|.| :.|..:.:.:.:...|:.|     |...|..|...|..|.|.:....::  :|..
Human   140 TDCEKGWAL-LKFGGKYYQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGP 203

  Fly    90 LQKSAELNPRNI------------------------ETYKEIGRTLYIM----------GRFSQA 120
            |:|:..|||.|.                        |...:|....|::          ..:::|
Human   204 LRKAVTLNPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYVLRYAAKFYRRKNSWNKA 268

  Fly   121 LGVFREAEQRSSRQDHEIYHYLGELLYRAATTQSQKDVASQQQ-------DE----ARTYFELAV 174
            |.:.::|.:.:..... ::|.:| |.|||...|.:|...::.:       ||    |..:|:.|:
Human   269 LELLKKALEVTPTSSF-LHHQMG-LCYRAQMIQIKKATHNRPKGKDKLKVDELISSAIFHFKAAM 331

  Fly   175 QSGRKLE-SYVRLAELYRKDKQYQKAIEI------LENC-----------------LHLTPENSE 215
            :...... :|..||.:|.:..||..|.:|      |||.                 .|...||:.
Human   332 ERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENITDDHKHQIHYHYGRFQEFHRKSENTA 396

  Fly   216 VLIEISVLYLKINETQKAHDRLAEV---VSIERKC----SPKGLLAFGAILQSRNDIDGALSKYS 273
            :...:..  ||:.:......:|...   :|.:|.|    ..:.|.|.|.:.:...:...|...|.
Human   397 IHHYLEA--LKVKDRSPLRTKLTSALKKLSTKRLCHNALDVQSLSALGFVYKLEGEKRQAAEYYE 459

  Fly   274 QIANAEPEIAELWNNIGLCFFKKQKFIVAISSLRKSV 310
            :....:||.||              |:.|:..||.|:
Human   460 KAQKIDPENAE--------------FLTALCELRLSI 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BBS4NP_610636.1 TPR_12 63..127 CDD:290160 17/99 (17%)
TPR repeat 68..95 CDD:276809 7/28 (25%)
TPR_12 97..175 CDD:290160 22/122 (18%)
TPR repeat 100..130 CDD:276809 7/63 (11%)
TPR repeat 136..175 CDD:276809 13/49 (27%)
TPR repeat 179..209 CDD:276809 11/53 (21%)
TPR_19 190..254 CDD:291240 18/93 (19%)
TPR repeat 214..242 CDD:276809 3/30 (10%)
TPR repeat 249..277 CDD:276809 5/27 (19%)
TPR_11 283..348 CDD:290150 7/28 (25%)
TPR repeat 283..311 CDD:276809 7/28 (25%)
TPR repeat 316..346 CDD:276809
TPR repeat 351..377 CDD:276809
IFIT5NP_036552.1 TPR_12 49..116 CDD:315987
TPR 1 51..84
TPR repeat 53..79 CDD:276809
TPR repeat 84..133 CDD:276809
TPR 2 94..127
TPR 3 138..173 6/33 (18%)
TPR repeat 138..168 CDD:276809 5/28 (18%)
PEP_TPR_lipo <157..470 CDD:274350 61/316 (19%)
TPR 4 181..214 9/32 (28%)
TPR repeat 214..244 CDD:276809 2/29 (7%)
TPR 5 249..282 4/32 (13%)
TPR repeat 249..277 CDD:276809 4/27 (15%)
Interaction with the 5'-triphosphate group of PPP-RNA 254..260 0/5 (0%)
TPR repeat 282..333 CDD:276809 13/52 (25%)
TPR 6 338..371 11/32 (34%)
TPR repeat 338..366 CDD:276809 8/27 (30%)
TPR 7 376..410 5/35 (14%)
TPR repeat 376..405 CDD:276809 3/30 (10%)
TPR 8 435..468 6/32 (19%)
TPR repeat 435..463 CDD:276809 5/27 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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