Protein Alignment BBS4 and Tmtc3

DIOPT Version :10

• Sequence 1: NP_610636.1
• Gene: BBS4 / 36167
• FlyBaseID: FBgn0033578
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_001103483.1
• Gene: Tmtc3 / 237500
• MGIID: 3036255
• Length: 920
• Species: Mus musculus
• Alignment Length: 444
• Identity: 97/444 - (21%)
• Similarity: 172/444 - (38%)
• Gaps: 77/444 - (17%)

  Fly    35 NIDWLLHIYFTRREFTRCRRLIERELNRHLNPEYLYFVQGLIDREEGNHIEALRHLQKSAELNPR 99
            |.||       ..|:|    |....|..:.|...|:...|.....|.|..:||::..::..:.|.
Mouse   430 NWDW-------ESEYT----LFMSALKVNKNNAKLWNNVGHALENEKNFEKALKYFLQATHVQPD 483

  Fly   100 NIETYKEIGRTLYIMGRFSQALGVFREAEQ-------------RSSRQDHEIYHYLGELLYRAAT 151
            :|..:..:|||...:.|..:|...:..|:.             |.:.....:|..|..|:....:
Mouse   484 DIGAHMNVGRTYKNLNRTREAEASYMLAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANES 548

  Fly   152 TQSQKDVASQQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQYQKAIEILENCLHLTPENSEV 216
            ...:.|...:|....|..|:         ::|:...||..|..:..||.|.....|.|...|:::
Mouse   549 RLEEADQLYRQAISMRPDFK---------QAYISRGELLLKMNKPLKAKEAYLKALELDRNNADL 604

  Fly   217 LIEISVLYLKI---NETQKAHDRLAEVVSIERKCSPKGLLAF---GAILQSRNDI---DGALSKY 272
            ...::::|:::   ||..|..:|..|:       :||..||.   ..::|...::   ..|..:.
Mouse   605 WYNLAIVYIELKEPNEALKNFNRALEL-------NPKHKLALFNSAILMQESGEVKLRPEARKRL 662

  Fly   273 SQIANAEPEIAELWNNIGLCFFKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIYIASEQYASAF 337
            ....|.||:.|..:.|:|:.....:|...|.|.::|::.|.|...:||:||:|:|..:.:...|.
Mouse   663 LNYVNEEPQDANGYFNLGMLAMDDKKDSEAESWMKKAIKLQPDFRSALFNLALLYSQTAKELKAL 727

  Fly   338 HTLAAAINLRKDNAECYMLLG-LCLRKLDDMENAFVALERASSMATGQQGAGRNPLVVLNF---- 397
            ..|...:....|:.:..:|.| :.:.:..|:..|....|:...|..... .|::.|.|:.|
Mouse   728 PILEELLKYYPDHTKGLILKGDILMNQKKDIPGAKKCFEKILEMDPSNV-QGKHNLCVVYFEEKE 791

  Fly   398 ---ALFC-YETGRLALSTEQYNRFMSQAQDLLLPTEYKFQATKLKSLLRISNQG 447
               |..| .||..||...|...|.:|..:|                  |||:.|
Mouse   792 LLKAERCLVETLALAPHEEYIQRHLSIVRD------------------RISSSG 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR repeat	68..95	CDD:276809	6/26 (23%)
		LapB	70..347	CDD:442196	63/298 (21%)
		TPR repeat	100..130	CDD:276809	7/42 (17%)
		TPR repeat	136..175	CDD:276809	7/38 (18%)
		TPR repeat	179..209	CDD:276809	8/29 (28%)
		TPR repeat	214..242	CDD:276809	6/30 (20%)
		TPR repeat	249..277	CDD:276809	6/33 (18%)
		BepA	281..423	CDD:443813	37/150 (25%)
		TPR repeat	283..311	CDD:276809	7/27 (26%)
		TPR repeat	316..346	CDD:276809	8/29 (28%)
		TPR repeat	351..377	CDD:276809	5/26 (19%)
Tmtc3	NP_001103483.1	TMTC_DUF1736	263..336	CDD:462468
		TPR	444..673	CDD:440225	49/244 (20%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	451..484		7/32 (22%)
		TPR repeat	451..479	CDD:276809	6/27 (22%)
		TPR repeat	484..528	CDD:276809	7/43 (16%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	485..518		7/32 (22%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	534..567		6/32 (19%)
		TPR repeat	535..562	CDD:276809	5/26 (19%)
		LapB	549..804	CDD:442196	61/271 (23%)
		TPR repeat	567..597	CDD:276809	9/38 (24%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	568..601		9/41 (22%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	602..635		7/39 (18%)
		TPR repeat	602..630	CDD:276809	5/27 (19%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	673..706		9/32 (28%)
		TPR repeat	673..702	CDD:276809	7/28 (25%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	707..740		8/32 (25%)
		TPR repeat	707..735	CDD:276809	8/27 (30%)
		TPR repeat	741..770	CDD:276809	5/28 (18%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	742..775		6/32 (19%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	776..809		10/33 (30%)
		TPR repeat	776..799	CDD:276809	5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	829..897