DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BBS4 and KDM6B

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001073893.1	Gene:	KDM6B / 23135	HGNCID:	29012	Length:	1682	Species:	Homo sapiens

Alignment Length:	330	Identity:	64/330 - (19%)
Similarity:	109/330 - (33%)	Gaps:	86/330 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 AVQSGRKLESYVRLAELYRKDKQYQKAIEILENCLHL--------------TPENSEVLIEISVL 223
            ::..|...|..:||.::...||:...|.|:.|..|.:              ...|::|..:....
Human  1094 SLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVVRASRNAKVKGKFRES 1158

  Fly   224 YLKINETQKAHDRLAEVVSIERKCSPKGLLAFGAILQSRNDIDGALSKYSQIANAEPEIAELWNN 288
            ||...::.|......|.:..|:...|...:    .|:|:.|   |.|         |.:.:...:
Human  1159 YLSPAQSVKPKINTEEKLPREKLNPPTPSI----YLESKRD---AFS---------PVLLQFCTD 1207

  Fly   289 IGLCFFKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAEC 353
                   .:..|..|..|..|:.|         ||.|....:...||..||:.....:::.:.|.
Human  1208 -------PRNPITVIRGLAGSLRL---------NLGLFSTKTLVEASGEHTVEVRTQVQQPSDEN 1256

  Fly   354 YMLLGL-----CLRKLDDMENAFVALERASSMATGQQ---------------GAGRNPLVV---L 395
            :.|.|.     |.........|..|..:|||.....|               ..|..|...   .
Human  1257 WDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSAPDPK 1321

  Fly   396 NFALFCYETGRLALSTEQYNRFMSQAQDLLLPTEYKFQATKLKSLLRISNQGNGILLDSADMGES 460
            |..:..:.|.   :......|:..|.|:||          ||.:.:|:::.||.:    :.:|.:
Human  1322 NHHIIKFGTN---IDLSDAKRWKPQLQELL----------KLPAFMRVTSTGNML----SHVGHT 1369

  Fly   461 DLGHN 465
            .||.|
Human  1370 ILGMN 1374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160
		TPR repeat	68..95	CDD:276809
		TPR_12	97..175	CDD:290160	0/1 (0%)
		TPR repeat	100..130	CDD:276809
		TPR repeat	136..175	CDD:276809	0/1 (0%)
		TPR repeat	179..209	CDD:276809	9/29 (31%)
		TPR_19	190..254	CDD:291240	14/77 (18%)
		TPR repeat	214..242	CDD:276809	5/27 (19%)
		TPR repeat	249..277	CDD:276809	6/27 (22%)
		TPR_11	283..348	CDD:290150	12/64 (19%)
		TPR repeat	283..311	CDD:276809	4/27 (15%)
		TPR repeat	316..346	CDD:276809	7/29 (24%)
		TPR repeat	351..377	CDD:276809	6/30 (20%)
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..680
		Mito_fiss_reg	<566..640	CDD:283069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..807
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..1096		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1325		4/36 (11%)
		JmjC	1343..1407	CDD:214721	13/46 (28%)
		JmjC	1377..1485	CDD:202224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900