DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BBS4 and TTC24

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001099139.2	Gene:	TTC24 / 164118	HGNCID:	32348	Length:	582	Species:	Homo sapiens

Alignment Length:	457	Identity:	94/457 - (20%)
Similarity:	161/457 - (35%)	Gaps:	144/457 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RPAPKMPSDANIDWLLHIYFTRREFTRCRRLIERELNRHLNPEYLYFVQGLIDREEG------NH 83
            ||.|: ||.:|            :..:.|:.:.:|.:          :|.|.....|      ||
Human    12 RPEPE-PSSSN------------KKKKKRKWLRQEAS----------IQALTRAGHGALQAGQNH 53

  Fly    84 IEALRHLQKS---AELNPRNIET-------------YKEIG---RTLYIMGRFSQALGVFREAEQ 129
             |||.:.|::   |...|:..:|             |.|.|   |.|.::.|        ...|:
Human    54 -EALNNFQRAFLLASKAPQTRDTPVLQACAFNLGAAYVETGDPARGLELLLR--------AHPEE 109

  Fly   130 RSSRQDHE--------IYHYLGELLYRAATTQSQKDVASQQQDEARTYFELAV----QSGRKLES 182
            ::..:.|.        .||.||||                  .:|..::..|:    ..|.:.|:
Human   110 KAQGRRHGDQCFNVALAYHALGEL------------------PQALAWYHRALGHYQPQGDQGEA 156

  Fly   183 YVRLAELYRKDKQYQKAIEILENCLHLTPENSEVLIEISVLYLKINETQKAHDRLAEVVSIERKC 247
            :.::...|:...|    .|:..:||.          |.|..|.:..:.:.|    |..:.....|
Human   157 WAKMGACYQALGQ----PELAAHCLQ----------EASQAYAQERQLRAA----ALALGAAAGC 203

  Fly   248 SPK-GLLAFGAILQSRNDIDGALSKYSQIANAEPE---IAELWNNIGLCFFKKQKFIVAISSLRK 308
            ..| |....|.::|       .|.|..::|....|   :..|:|::||.:.:.|.|.:|:.:..:
Human   204 MLKSGRHRVGEVVQ-------VLEKSRRLAERSTERRLLGHLYNDLGLGYSQLQLFPLAVEAFLQ 261

  Fly   309 SV---WLSPLNYNALYNLSLIYIASEQYASA--FHTLAA----AINLRKDNAECYMLLGLCLRKL 364
            ::   |:.......|.||.:.:.|...|..|  ||..||    ::..|.:....:..|...|.:|
Human   262 ALPLCWVPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQL 326

  Fly   365 DD----MENAFVALE--RASSMATGQQGAGRNPLVVLNFALFCYETGRLALSTEQYNRFMSQAQD 423
            .|    .:|...||:  |.|....||..|             |...|..|....||::.:...::
Human   327 GDHKAARDNYLHALQAARDSGDMKGQWQA-------------CEGLGAAAARLGQYDQALKYYKE 378

  Fly   424 LL 425
            .|
Human   379 AL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	18/88 (20%)
		TPR repeat	68..95	CDD:276809	9/35 (26%)
		TPR_12	97..175	CDD:290160	18/105 (17%)
		TPR repeat	100..130	CDD:276809	8/45 (18%)
		TPR repeat	136..175	CDD:276809	9/50 (18%)
		TPR repeat	179..209	CDD:276809	6/29 (21%)
		TPR_19	190..254	CDD:291240	13/64 (20%)
		TPR repeat	214..242	CDD:276809	5/27 (19%)
		TPR repeat	249..277	CDD:276809	6/28 (21%)
		TPR_11	283..348	CDD:290150	18/73 (25%)
		TPR repeat	283..311	CDD:276809	7/30 (23%)
		TPR repeat	316..346	CDD:276809	10/35 (29%)
		TPR repeat	351..377	CDD:276809	7/31 (23%)
TTC24	NP_001099139.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		7/31 (23%)
		TPR_12	36..105	CDD:290160	18/77 (23%)
		TPR 1	36..69		10/33 (30%)
		TPR repeat	36..64	CDD:276809	9/28 (32%)
		TPR 2	79..112		7/40 (18%)
		TPR_12	80..148	CDD:290160	16/93 (17%)
		TPR repeat	81..111	CDD:276809	7/37 (19%)
		TPR repeat	116..146	CDD:276809	9/47 (19%)
		TPR 3	117..150		8/50 (16%)
		TPR_11	121..180	CDD:290150	15/90 (17%)
		TPR 4	154..187		9/46 (20%)
		TPR repeat	154..180	CDD:276809	6/39 (15%)
		TPR_12	232..302	CDD:290160	18/69 (26%)
		TPR 5	236..271		8/34 (24%)
		TPR repeat	238..264	CDD:276809	7/25 (28%)
		TPR_12	271..345	CDD:290160	18/73 (25%)
		TPR 6	273..306		10/32 (31%)
		TPR	273..302	CDD:197478	10/28 (36%)
		TPR repeat	273..301	CDD:276809	9/27 (33%)
		TPR repeat	312..342	CDD:276809	7/29 (24%)
		TPR 7	313..346		8/32 (25%)
		TPR_12	314..385	CDD:290160	18/80 (23%)
		TPR 8	353..386		7/41 (17%)
		TPR repeat	353..381	CDD:276809	7/41 (17%)
		TPR_1	353..>380	CDD:278916	6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..481
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..582
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900