DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BBS4 and TTC16

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_659402.1	Gene:	TTC16 / 158248	HGNCID:	26536	Length:	873	Species:	Homo sapiens

Alignment Length:	618	Identity:	109/618 - (17%)
Similarity:	202/618 - (32%)	Gaps:	208/618 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VRPAPKMPSDANIDWLLHIYFT-----------------------RREFTRCRRLIERE------ 59
            |.||||       ..|.||:.|                       |..::|.::.:|:.
Human    24 VIPAPK-------GILQHIFGTSHVFQSICDVKPKVTGLTVPLKVREYYSRGQQCLEQADWETAV 81

  Fly    60 --LNR--HLNPEYLYFVQGLID----REEG-----NHIEALRHLQKSAELNPRNIETYKEIGRTL 111
              .:|  ||:|:       |:|    |.|.     :...|.::|:::..|...|.:..:.:...|
Human    82 LLFSRALHLDPQ-------LVDFYALRAEAYLQLCDFSSAAQNLRRAYSLQQDNCKHLERLTFVL 139

  Fly   112 YIMGR-------FSQALGVF-----------------------------------REAEQRSSRQ 134
            |:.|:       |..||.||                                   .|.:|.::..
Human   140 YLQGQCLFEQCAFLDALNVFSHAAELQPEKPCFRYRCMACLLALKQHQACLTLITNELKQDTTNA 204

  Fly   135 D-----HEIYHYLGE--LLYR-------------AATTQSQKDVASQQQDEARTYFELAVQS--- 176
            |     ..:|::|.:  |.||             .|....||.||..||....... ||||.
Human   205 DVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQARMLLQKMVAQAQQARQDAGI-LAVQGKLQ 268

  Fly   177 ------GRKLES-------YVRLAELYRKDKQYQKAIEILENCLHLTPENSEVLIEISVLYLKIN 228
                  .|.:|:       ::....:||:.:::..|:|.....|.:..|:.|.::.
Human   269 HALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQEDMVR--------- 324

  Fly   229 ETQKAHDRLAEVVSIERKCSPKGLLAFGAILQSRNDIDGALSKYSQIANAEPEIAELWNNIGLCF 293
              |.....|.........|..:|....|.:|.::...|            |.:...|:.|.|.||
Human   325 --QAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRD------------EQQEKGLYINRGDCF 375

  Fly   294 FKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIY-------IASEQYASAFHTLAAAINLRKDNA 351
            |:......|.:..::::.|||.:..|...:.|:.       ...:|:..|.:..:.||......|
Human   376 FQLGNLAFAEADYQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKA 440

  Fly   352 ECYM---------------------------------LL------GLCLRKLDDMENAFVALERA 377
            :.|:                                 ||      |:.:.::...:.|.:|..:.
Human   441 QYYLYRAKSRQLLQNIFGARQDVATVLLLNPKQPKLSLLMTNLFPGMSVEEVLSTQIAHLARLQL 505

  Fly   378 SSMATGQQGAGRNPLVVLNFALFCYETGRLALSTEQYNRFMSQAQDLLLPTEYKFQATKLKSLLR 442
            ..|..|...|| :|..::.. |..:|..|......|::  ..|.:.|:..:|......::..:..
Human   506 EQMVEGSLQAG-SPQGIVGM-LKRHELERQKALALQHS--WKQGEPLIATSEELKATPEIPQVKP 566

  Fly   443 ISNQGNGILLDSADMGESDLGHNRATELLPDEL 475
            .|::|.....:..:..|.:....:.:||:|.::
Human   567 GSSEGEAEAPEEEEEKEKEKKEEKKSELIPSKV 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	19/114 (17%)
		TPR repeat	68..95	CDD:276809	6/35 (17%)
		TPR_12	97..175	CDD:290160	26/139 (19%)
		TPR repeat	100..130	CDD:276809	10/71 (14%)
		TPR repeat	136..175	CDD:276809	14/53 (26%)
		TPR repeat	179..209	CDD:276809	6/36 (17%)
		TPR_19	190..254	CDD:291240	11/63 (17%)
		TPR repeat	214..242	CDD:276809	3/27 (11%)
		TPR repeat	249..277	CDD:276809	4/27 (15%)
		TPR_11	283..348	CDD:290150	16/71 (23%)
		TPR repeat	283..311	CDD:276809	7/27 (26%)
		TPR repeat	316..346	CDD:276809	6/36 (17%)
		TPR repeat	351..377	CDD:276809	7/64 (11%)
TTC16	NP_659402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		TPR 1	61..94		7/39 (18%)
		TPR repeat	61..89	CDD:276809	4/27 (15%)
		TPR_11	62..124	CDD:290150	13/68 (19%)
		TPR repeat	94..124	CDD:276809	6/29 (21%)
		TPR 2	96..128		6/31 (19%)
		TPR repeat	129..164	CDD:276809	8/34 (24%)
		TPR 3	136..169		8/32 (25%)
		TPR repeat	169..199	CDD:276809	1/29 (3%)
		TPR repeat	204..231	CDD:276809	6/26 (23%)
		TPR repeat	237..280	CDD:276809	12/43 (28%)
		TPR 4	251..284		8/33 (24%)
		TPR_11	<264..314	CDD:290150	8/49 (16%)
		TPR 5	285..318		5/32 (16%)
		TPR repeat	285..313	CDD:276809	4/27 (15%)
		TPR 6	331..364		7/44 (16%)
		TPR_11	332..396	CDD:290150	14/75 (19%)
		TPR repeat	333..359	CDD:276809	4/25 (16%)
		TPR repeat	364..394	CDD:276809	7/29 (24%)
		TPR 7	365..398		10/32 (31%)
		TPR_11	367..437	CDD:290150	16/69 (23%)
		TPR_1	368..398	CDD:278916	9/29 (31%)
		TPR repeat	399..434	CDD:276809	5/34 (15%)
		TPR 8	406..439		5/32 (16%)
		TPR_11	407..471	CDD:290150	7/63 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..626		7/47 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..873
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900