DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BBS4 and TOMM34

DIOPT Version :9

Sequence 1:NP_610636.1 Gene:BBS4 / 36167 FlyBaseID:FBgn0033578 Length:486 Species:Drosophila melanogaster
Sequence 2:NP_006800.2 Gene:TOMM34 / 10953 HGNCID:15746 Length:309 Species:Homo sapiens


Alignment Length:312 Identity:59/312 - (18%)
Similarity:113/312 - (36%) Gaps:70/312 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 PRNIETYKEIGRTLYIMGRFSQALGVFREA-----EQRSSRQDHEIYHYLGELLY--RAATTQSQ 155
            |.::|..:..|...:..|::::|..::..|     .|.||..:.|      .:||  |||.....
Human     6 PDSVEELRAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEE------SVLYSNRAACHLKD 64

  Fly   156 -------KDVASQQQDEARTYFELAVQS-GRKLESYVRLAELYRKDKQYQKAIEILENCL----- 207
                   ||..|     |......:::. .|:..:|..|.:.......|:..::|.:|..     
Human    65 GNCRDCIKDCTS-----ALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEG 124

  Fly   208 ----------HLTPE-----NSEVLIEIS---------------VLYLKINETQKAHDRLAEVVS 242
                      .|.||     .|..|:.:|               :...|..||....:|:.....
Human   125 INRMTRALMDSLGPEWRLKLPSIPLVPVSAQKRWNSLPSENHKEMAKSKSKETTATKNRVPSAGD 189

  Fly   243 IERKCSPKGLLAFGAILQSRNDIDGALSKYSQ---IANAEPEIAELWNNIGLCFFKKQKFIVAIS 304
            :|:   .:.|...|..|..:.:...|:.|||:   .:|.|   :..::|..||:...:::..|:.
Human   190 VEK---ARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLE---SATYSNRALCYLVLKQYTEAVK 248

  Fly   305 SLRKSVWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAECYML 356
            ...:::.|...|..|.|..:..:.|.:.|.|:|..::..:.:...|.....|
Human   249 DCTEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIEPRNGPAQKL 300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BBS4NP_610636.1 TPR_12 63..127 CDD:290160 5/28 (18%)
TPR repeat 68..95 CDD:276809
TPR_12 97..175 CDD:290160 19/90 (21%)
TPR repeat 100..130 CDD:276809 5/34 (15%)
TPR repeat 136..175 CDD:276809 10/47 (21%)
TPR repeat 179..209 CDD:276809 5/44 (11%)
TPR_19 190..254 CDD:291240 15/98 (15%)
TPR repeat 214..242 CDD:276809 7/42 (17%)
TPR repeat 249..277 CDD:276809 7/30 (23%)
TPR_11 283..348 CDD:290150 12/64 (19%)
TPR repeat 283..311 CDD:276809 4/27 (15%)
TPR repeat 316..346 CDD:276809 7/29 (24%)
TPR repeat 351..377 CDD:276809 1/6 (17%)
TOMM34NP_006800.2 TPR 1 9..42 5/32 (16%)
TPR repeat 9..37 CDD:276809 5/27 (19%)
PLN03088 <12..>294 CDD:330826 55/298 (18%)
TPR repeat 50..80 CDD:276809 10/40 (25%)
TPR 2 51..84 9/37 (24%)
TPR repeat 85..113 CDD:276809 4/27 (15%)
TPR 3 86..118 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..189 4/27 (15%)
TPR 4 193..226 8/32 (25%)
TPR repeat 193..221 CDD:276809 7/27 (26%)
TPR repeat 226..256 CDD:276809 5/32 (16%)
TPR 5 227..260 5/32 (16%)
TPR repeat 261..289 CDD:276809 6/27 (22%)
TPR 6 262..294 6/31 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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