DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and tmtc3

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_001922486.4	Gene:	tmtc3 / 100150181	ZFINID:	ZDB-GENE-061221-2	Length:	932	Species:	Danio rerio

Alignment Length:	525	Identity:	111/525 - (21%)
Similarity:	182/525 - (34%)	Gaps:	150/525 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NIDWLLHIYFTRREFTRCRRLIERELNRHLNPEYLYFVQGLIDREEGNHIEALRHLQKSAELNPR 99
            |.||       ..|:|    |....|..:.|...|:...|.....:.::..|||:..::..:.|.
Zfish   425 NWDW-------ESEYT----LFTSALKVNRNNAKLWNNVGHALENQNSYERALRYFLQATRVQPD 478

  Fly   100 NIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEIYHYLGELLYRAATTQSQKDVASQQQD 164
            :|..:..:|||...:.|               ||:..|.|     |:.::...|
Zfish   479 DIGAHMNVGRTYKNLNR---------------SREAEEAY-----LIAKSLMPQ----------- 512

  Fly   165 EARTYFELAVQSGRK---------LESYVRLAELYR-KDKQYQKAIEILENCLHLTPENSEVLIE 219
                     :..|:|         |..|:.||.|.| .|.:.::|.::....:.:.|:..:..|.
Zfish   513 ---------IIPGKKYATRVAPNHLNVYINLANLIRANDSRLEEADQLYRQAISMRPDFKQAYIS 568

  Fly   220 ISVLYLKINETQKAHD---RLAE-------------VVSIERK--------------CSPKGLLA 254
            ...|.||:|:..:|.|   |..|             :|:||.|              .:|:..||
Zfish   569 RGELLLKMNKPSEAKDAYLRALELDHTNADLWYNLAIVNIEMKDPSEALRNFNRALDLNPRHKLA 633

  Fly   255 -FGAILQSRNDIDGAL-----SKYSQIANAEPEIAELWNNIGLCFFKKQKFIVAISSLRKSVWLS 313
             |.:.|..:...:..|     .::......||:.|..:.|:|:......:...|...:|:::.|.
Zfish   634 LFNSALLMQESGEAKLRPEANRRFLTYVKEEPDDANGYFNLGMLAMDANENEEAEHWMREAIHLQ 698

  Fly   314 PLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAECYMLLG-LCLRKLDDMENAFVALERA 377
            |...:||:||:|:|..|::...|...|...:....::.:..:|.| :.:....|...|....||.
Zfish   699 PGFRSALFNLALLYSQSQRELDALPVLEELLRYHPEHVKGLILKGDILMNHRKDTRGAKTCFERI 763

  Fly   378 SSMATGQQGAGRNPLVV------LNFALFCYETGRLALSTEQYNR-----------FMSQAQDLL 425
            .||......|..|..||      |..|..|..........|:|.|           .||.|...:
Zfish   764 LSMDPSNVQAKHNLCVVYFEERELQRAERCLVDTLAMAPQEEYIRRHLAIVRNKMAAMSAAGQPI 828

  Fly   426 LPTE-----YKFQ--------------------------ATKLKSLLRIS---NQGNGILLDSAD 456
            .|||     .|.|                          |.|.|:|.:.|   |||:| ..:..|
Zfish   829 APTEGGSMSDKQQGHQPEDKKEEEEEEEGRGVASGAGEGARKEKNLRKSSSTENQGHG-QSEKLD 892

  Fly   457 MGESD 461
            .|:.|
Zfish   893 TGQPD 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	12/63 (19%)
		TPR repeat	68..95	CDD:276809	5/26 (19%)
		TPR_12	97..175	CDD:290160	12/77 (16%)
		TPR repeat	100..130	CDD:276809	5/29 (17%)
		TPR repeat	136..175	CDD:276809	4/38 (11%)
		TPR repeat	179..209	CDD:276809	9/39 (23%)
		TPR_19	190..254	CDD:291240	18/94 (19%)
		TPR repeat	214..242	CDD:276809	9/43 (21%)
		TPR repeat	249..277	CDD:276809	6/33 (18%)
		TPR_11	283..348	CDD:290150	16/64 (25%)
		TPR repeat	283..311	CDD:276809	5/27 (19%)
		TPR repeat	316..346	CDD:276809	9/29 (31%)
		TPR repeat	351..377	CDD:276809	5/26 (19%)
tmtc3	XP_001922486.4	DUF1736	258..331	CDD:285594
		TPR_11	<434..477	CDD:290150	8/42 (19%)
		TPR repeat	445..475	CDD:276809	5/29 (17%)
		TPR_1	446..479	CDD:278916	6/32 (19%)
		TPR	462..757	CDD:223533	66/334 (20%)
		TPR repeat	480..506	CDD:276809	10/45 (22%)
		TPR repeat	530..557	CDD:276809	7/26 (27%)
		TPR repeat	562..592	CDD:276809	8/29 (28%)
		TPR_1	564..596	CDD:278916	9/31 (29%)
		TPR_1	597..630	CDD:278916	5/32 (16%)
		TPR repeat	597..625	CDD:276809	4/27 (15%)
		TPR repeat	667..697	CDD:276809	5/29 (17%)
		TPR repeat	702..730	CDD:276809	9/27 (33%)
		TPR repeat	736..765	CDD:276809	6/28 (21%)
		TPR_11	739..802	CDD:290150	15/62 (24%)
		TPR repeat	771..794	CDD:276809	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900