DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn47C and Serpind1

DIOPT Version :9

Sequence 1:	NP_001163116.1	Gene:	Spn47C / 36163	FlyBaseID:	FBgn0033574	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	107/385 - (27%)
Similarity:	185/385 - (48%)	Gaps:	41/385 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FARNLFRALNDEVPPV-NMMVSPAGARSAMTLVFMGAGGKSADELRSKL----ILGVSNKSEVAK 77
            ||.||:|.|.|:.... |:.::|.|..:||.::.:|..|::.:|:.|.|    .:..|:|.||..
  Rat   113 FAFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHSVLHFKDFVNASSKYEVTT 177

  Fly    78 QH--AESWTDECSCAKKGVALRLVTRLYVNEEEKIRTDFNDMALEFFNAEAYSLNYLNPEDSVKK 140
            .|  ....|........|..|:.|..||:.::..||.||.....||:.|||...::.:|. .:.|
  Rat   178 IHNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKAAMREFYFAEAQEADFSDPA-FISK 241

  Fly   141 VNKWLEKHTFYTVRNLFTPEVFNSDSS--VILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQRME 203
            .|    .|.....:.|....:.|:||:  ::::|.::|:..|...||.::|...:|.:|.|:.::
  Rat   242 AN----SHILKLTKGLIKEALENTDSATQMMILNCIYFKGAWMNKFPVEMTHNHNFRLNEREVVK 302

  Fly   204 VSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEKLGQLDMNEVAAKSL 268
            ||||:..|.|.....::|...||||.:. ..::|:|::|..:.|:..||.:|.. .:.|...||:
  Rat   303 VSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVIPRKLSGMKTLEAQLTP-QVVERWQKSM 365

  Fly   269 MKEV-DVTIPKFRIECTVDLKVPLQKMGINSVFD-----AGQAD---LSDLFEMKTPQKISEARH 324
            .... :|.:|||::|...:|...|:.|||..:|:     :|.:|   :.|||           :|
  Rat   366 TNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGISDQRIIIDLF-----------KH 419

  Fly   325 KVFLNVTEFGCEVAPEAEVQPEVLKKNPDRKFFKADRPFVFAIRDRKN--VYFVGHFVKP 382
            :..:.|.|.|.:.|....|....|.   .:..|..||||:|.:.:.:.  :.|:|....|
  Rat   420 QSTITVNEEGTQAAAVTTVGFMPLS---TQVRFTVDRPFLFLVYEHRTSCLLFMGRVANP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_001163116.1	SERPIN	18..379	CDD:238101	106/380 (28%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	107/385 (28%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020