DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn47C and Serpinb1a

DIOPT Version :9

Sequence 1:	NP_001163116.1	Gene:	Spn47C / 36163	FlyBaseID:	FBgn0033574	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_079705.2	Gene:	Serpinb1a / 66222	MGIID:	1913472	Length:	379	Species:	Mus musculus

Alignment Length:	402	Identity:	112/402 - (27%)
Similarity:	197/402 - (49%)	Gaps:	56/402 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LSASPIVFARNLFRALNDEVPPVNMMVSPAGARSAMTLVFMGAGGKSADELRSKLILGVSNKSEV 75
            ||::..:||..||:.||:..|..|:..||....||:.:|.:||.|.:|.:| ||..    :...|
Mouse     4 LSSANTLFALELFQTLNESSPTGNIFFSPFSISSALAMVILGAKGSTAAQL-SKTF----HFDSV 63

  Fly    76 AKQHAESWTDECSCAKKGVA--LRLVTRLYVNEEEKIRTDFNDMALEFFNAEAYSLNYLN-PEDS 137
            ...|:...:.....:|:|.:  |:|..|||..:......::.....:.:.|:...:::|: .||:
Mouse    64 EDIHSRFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLPEYLASTQKMYGADLAPVDFLHASEDA 128

  Fly   138 VKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQRM 202
            .|::|:|::..|...:..|.:..|.:|.:.::|||:::|:..|.:.|..:.|....|.::.:...
Mouse   129 RKEINQWVKGQTEGKIPELLSVGVVDSMTKLVLVNAIYFKGMWEEKFMTEDTTDAPFRLSKKDTK 193

  Fly   203 EVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAID----GLPELEEKLGQLDMNEV 263
            .|.||.|..:|.:|....||.::|::|::...|:|:|:||..|:    ||.::|:::....:.|.
Mouse   194 TVKMMYQKKKFPFGYISDLKCKVLEMPYQGGELSMVILLPKDIEDESTGLKKIEKQITLEKLLEW 258

  Fly   264 AAKSLMKEVD--VTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLS------DLFEMKTPQKIS 320
            ..:..::.:|  |.:|:|:||.:..|...|.::|:..:|.:.:||||      |||       ||
Mouse   259 TKRENLEFIDVHVKLPRFKIEESYTLNSNLGRLGVQDLFSSSKADLSGMSGSRDLF-------IS 316

  Fly   321 EARHKVFLNVTEFGCEVA-------------PEAEVQPEVLKKNPDRKFFKADRPFVFAIRDR-- 370
            :..||.|:.|.|.|.|.|             ||.|              |..|.||:|.||..
Mouse   317 KIVHKSFVEVNEEGTEAAAATGGIATFCMLLPEEE--------------FTVDHPFIFFIRHNPT 367

  Fly   371 KNVYFVGHFVKP 382
            .||.|:|....|
Mouse   368 SNVLFLGRVCSP 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_001163116.1	SERPIN	18..379	CDD:238101	109/390 (28%)
Serpinb1a	NP_079705.2	serpinB1_LEI	1..379	CDD:381028	111/400 (28%)
Serpinb1a	NP_079705.2	CARD-binding motif (CBM). /evidence=ECO:0000250\|UniProtKB:P30740	351..379		12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920