DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn47C and SERPINB4

DIOPT Version :9

Sequence 1:	NP_001163116.1	Gene:	Spn47C / 36163	FlyBaseID:	FBgn0033574	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	392	Identity:	113/392 - (28%)
Similarity:	203/392 - (51%)	Gaps:	23/392 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SLSASPIVFARNLFRALNDEVPPVNMMVSPAGARSAMTLVFMGAGGKSADELRSKLI----LGVS 70
            |||.:...|..:||:... :....|:..||....||:.:|.:||...:|.:: ||::    :..:
Human     3 SLSEANTKFMFDLFQQFR-KSKENNIFYSPISITSALGMVLLGAKDNTAQQI-SKVLHFDQVTEN 65

  Fly    71 NKSEVAKQHA----------ESWTDECSCAKKGVALRLVTRLYVNEEEKIRTDFNDMALEFFNAE 125
            ...:.|..|.          :....|.:.:.....|::..:|:..:..:...::.|...:|:...
Human    66 TTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTS 130

  Fly   126 AYSLNYLN-PEDSVKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLT 189
            ..|.::.| ||:|.||:|.|:|..|...::|||......:|::::|||:::|:.:|...|.::.|
Human   131 VESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENT 195

  Fly   190 QIDDFWINPRQRMEVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEK 254
            :.:.||.|......|.||||...|.:...:.:::::|::|::..:|:|:::||..||||.:||||
Human   196 KEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEK 260

  Fly   255 LGQLDMNEVAAKSLMKE--VDVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLSDLFEMKTPQ 317
            |....:.|..:...|:|  ||:.:|:|::|.:.|||..|:.||:.::|: |.||||.: ......
Human   261 LTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFN-GDADLSGM-TWSHGL 323

  Fly   318 KISEARHKVFLNVTEFGCEVAPEAEVQPEVLKKNPDRKFFKADRPFVFAIRDRK--NVYFVGHFV 380
            .:|:..||.|:.|||.|.|.|....|....|......:.|..:.||:|.||..|  ::.|.|.|.
Human   324 SVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFS 388

  Fly   381 KP 382
            .|
Human   389 SP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_001163116.1	SERPIN	18..379	CDD:238101	108/379 (28%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	111/389 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920