DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn47C and SERPINB3

DIOPT Version :9

Sequence 1:	NP_001163116.1	Gene:	Spn47C / 36163	FlyBaseID:	FBgn0033574	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_008850.1	Gene:	SERPINB3 / 6317	HGNCID:	10569	Length:	390	Species:	Homo sapiens

Alignment Length:	395	Identity:	113/395 - (28%)
Similarity:	199/395 - (50%)	Gaps:	29/395 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SLSASPIVFARNLFRALNDEVPPVNMMVSPAGARSAMTLVFMGAGGKSADELRSKL--------- 65
            |||.:...|..:||:... :....|:..||....||:.:|.:||...:|.:::..|
Human     3 SLSEANTKFMFDLFQQFR-KSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENT 66

  Fly    66 -----ILGVSNKSEVAKQHAESWTDECSCAKKGVALRLVTRLYVNEEEKIRTDFNDMALEFFNAE 125
                 ...|.....|..|..:..| |.:.:.....|::..:|:..:......::.|...:|:...
Human    67 TGKAATYHVDRSGNVHHQFQKLLT-EFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTS 130

  Fly   126 AYSLNYLN-PEDSVKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLT 189
            ..|:::.| ||:|.||:|.|:|..|...::||.......|:::::|||:::|:.:|.|.|.::.|
Human   131 VESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDT 195

  Fly   190 QIDDFWINPRQRMEVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEK 254
            :.:.||.|......:.||||...|.:...:.:::::|::|::..:|:|:::||..||||.:||||
Human   196 KEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEK 260

  Fly   255 LGQLDMNEVAAKSLMKE--VDVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLSDLFEMKTPQ 317
            |....:.|..:...|:|  ||:.:|:|::|.:.|||..|:.||:..:|: |.||||.:    |..
Human   261 LTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFN-GDADLSGM----TGS 320

  Fly   318 K---ISEARHKVFLNVTEFGCEVAPEAEVQPEVLKKNPDRKFFKADRPFVFAIRDRK--NVYFVG 377
            :   :|...||.|:.|||.|.|.|....|...........:.|..:.||:|.||..|  ::.|.|
Human   321 RGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYG 385

  Fly   378 HFVKP 382
            .|..|
Human   386 RFSSP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_001163116.1	SERPIN	18..379	CDD:238101	108/382 (28%)
SERPINB3	NP_008850.1	serpinB3_B4_SCCA1_2	1..390	CDD:381030	112/393 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820