DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn47C and SERPINE2

DIOPT Version :9

Sequence 1:	NP_001163116.1	Gene:	Spn47C / 36163	FlyBaseID:	FBgn0033574	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_005246698.1	Gene:	SERPINE2 / 5270	HGNCID:	8951	Length:	410	Species:	Homo sapiens

Alignment Length:	409	Identity:	101/409 - (24%)
Similarity:	187/409 - (45%)	Gaps:	57/409 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TAPSLSA--SPIVFAR-------NLFRALNDEVPPVNMMVSPAGARSAMTLVFMGAGGKSADELR 62
            |.||:.:  :|:....       .:|..:....|..|:::||.|..|.:.::.:||.|::..:|.
Human    26 TLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLA 90

  Fly    63 SKLILGVS---------NKSEVAKQHAESWTDECSCAKKGVALRLVTRLYVNEEEKIRTDFNDMA 118
            ..:..||:         ||:.|:|::.:..|             :...::|....:|...|....
Human    91 MVMRYGVNGVGKILKKINKAIVSKKNKDIVT-------------VANAVFVKNASEIEVPFVTRN 142

  Fly   119 LEFFNAEAYSLNYLNPEDSVKKVNKWLEKHTFYTVRNLFTPEVFNSD-SSVILVNSLFFRAKWNK 182
            .:.|..|..::|:.:|..:...:|.|::..|...:.||.:|::.:.. :.::|||:::|:..|..
Human   143 KDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKS 207

  Fly   183 IFPQQLTQIDDFWINPRQRMEVSMMRQIGQFRYGES---KKLKSQILQLPFERSNLTMMIILPT- 243
            .|..:.|:...|.....:..:|.|:.|:..||.|.:   ..|....::||:...:::|:|.|||
Human   208 RFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 272

  Fly   244 ------AIDGLPELEEKLGQLDMNEVAAKSLM--KEVDVTIPKFRIECTVDLKVPLQKMGINSVF 300
                  ||  :|.:..|  .:|    :..|:|  |.|.|.:|||......|||.||:.:||..:|
Human   273 SSTPLSAI--IPHISTK--TID----SWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMF 329

  Fly   301 DAGQADLSDLFEMKTPQKISEARHKVFLNVTEFGCEVAPEAEVQPEVLKKNPDRKFFKADRPFVF 365
            |:.:|:.:.:........:|....|..:.|:|.|.: |..|.....:.:.:|  .:|..||||:|
Human   330 DSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTK-ASAATTAILIARSSP--PWFIVDRPFLF 391

  Fly   366 AIRDRKN--VYFVGHFVKP 382
            .||....  |.|:|...||
Human   392 FIRHNPTGAVLFMGQINKP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_001163116.1	SERPIN	18..379	CDD:238101	95/391 (24%)
SERPINE2	XP_005246698.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020