Protein Alignment Spn47C and SERPINC1

DIOPT Version :10

• Sequence 1: NP_610633.1
• Gene: Spn47C / 36163
• FlyBaseID: FBgn0033574
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 108/432 - (25%)
• Similarity: 184/432 - (42%)
• Gaps: 72/432 - (16%)

  Fly    11 LSASPIVFARNLFRAL------NDEVPPVNMMVSPAGARSAMTLVFMGAGGKSADELRSKLILGV 69
            ||.:...||...::.|      ||     |:.:||....:|..:..:||...:..:|..  :...
Human    83 LSKANSRFATTFYQHLADSKNDND-----NIFLSPLSISTAFAMTKLGACNDTLQQLME--VFKF 140

  Fly    70 SNKSEVAKQHAESWTDECSC-----AKKGVALRLVTRLYVNEEEKIRTDFNDMALEFFNAEAYSL 129
            ...||........:..:.:|     |.|...|....||:.::.......:.|::...:.|:...|
Human   141 DTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPL 205

  Fly   130 NYL-NPEDSVKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRA--------------- 178
            ::. |.|.|...:|||:...|...:.::...|..|..:.::|||:::|:.
Human   206 DFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKVLRMALERPQGLPLAL 270

  Fly   179 -------KWNKIFPQQL-------------------TQIDDFWINPRQRMEVSMMRQIGQFRYGE 217
                   ||....|::.                   |:.:.|:....:....|||.|.|:|||..
Human   271 QLTPFFFKWRDRSPERANGLPKATQGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRR 335

  Fly   218 SKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEKLG----QLDMNEVAAKSLMKEVDVTIPK 278
            ..: .:|:|:|||:..::||::|||.....|.::|::|.    |..::|:....|:    |.:|:
Human   336 VAE-GTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLV----VHMPR 395

  Fly   279 FRIECTVDLKVPLQKMGINSVFDAGQADLSDLF-EMKTPQKISEARHKVFLNVTEFGCEVAPEAE 342
            ||||....||..||.||:..:|...::.|..:. |.:....:|:|.||.||.|.|.|.|.|....
Human   396 FRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTA 460

  Fly   343 VQPEVLKKNPDRKFFKADRPFVFAIRD--RKNVYFVGHFVKP 382
            |.......||:|..|||:|||:..||:  ...:.|:|....|
Human   461 VVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANP 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_610633.1	serpin42Dd-like_insects	13..382	CDD:381070	105/428 (25%)
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	108/432 (25%)