DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn47C and SERPIND1

DIOPT Version :9

Sequence 1:	NP_001163116.1	Gene:	Spn47C / 36163	FlyBaseID:	FBgn0033574	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	384	Identity:	104/384 - (27%)
Similarity:	180/384 - (46%)	Gaps:	39/384 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FARNLFRALNDEVPPV-NMMVSPAGARSAMTLVFMGAGGKSADELRS----KLILGVSNKSEVAK 77
            ||.||:|.|.|:|... |:.::|.|..:||.::.:|..|::.:::.|    |..:..|:|.|:..
Human   133 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITT 197

  Fly    78 QH--AESWTDECSCAKKGVALRLVTRLYVNEEEKIRTDFNDMALEFFNAEAYSLNYLNPEDSVKK 140
            .|  ....|........|..||.|..||:.::..|..||.....|::.|||...::.:|. .:.|
Human   198 IHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPA-FISK 261

  Fly   141 VNKWLEKHTFYTVRNLFTPEVFNSD--SSVILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQRME 203
            .|..:.|.|    :.|....:.|.|  :.::::|.::|:..|...||.::|...:|.:|.|:.::
Human   262 TNNHIMKLT----KGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVK 322

  Fly   204 VSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEKLGQLDMNEVAAKSL 268
            ||||:..|.|.....::|...||||.:. ..::|:|::|..:.|:..||.:|....:........
Human   323 VSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMT 386

  Fly   269 MKEVDVTIPKFRIECTVDLKVPLQKMGINSVFD-----AGQAD---LSDLFEMKTPQKISEARHK 325
            .:..:|.:|||::|...:|...|:.|||..:||     ||.:|   ..|||           :|:
Human   387 NRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLF-----------KHQ 440

  Fly   326 VFLNVTEFGCEVAPEAEVQPEVLKKNPDRKFFKADRPFVFAIRDRKN--VYFVGHFVKP 382
            ..:.|.|.|.:......|....|.   .:..|..||||:|.|.:.:.  :.|:|....|
Human   441 GTITVNEEGTQATTVTTVGFMPLS---TQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_001163116.1	SERPIN	18..379	CDD:238101	103/379 (27%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	104/384 (27%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020