Protein Alignment Spn47C and SERPINB1

DIOPT Version :10

• Sequence 1: NP_610633.1
• Gene: Spn47C / 36163
• FlyBaseID: FBgn0033574
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 116/396 - (29%)
• Similarity: 205/396 - (51%)
• Gaps: 44/396 - (11%)

  Fly    11 LSASPIVFARNLFRALNDEVPPVNMMVSPAGARSAMTLVFMGAGGKSADELRSKLILGVSNKSEV 75
            ||::...||.:||.||::..|..|:.:||....|||.:||:|..|.:|.:| ||..    :.:.|
Human     4 LSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQL-SKTF----HFNTV 63

  Fly    76 AKQHAESWTDECSCAKKGVA--LRLVTRLYVNEEEKIRTDFNDMALEFFNAEAYSLNYLN-PEDS 137
            .:.|:...:......|:|.:  |:|..|||..:......:|.....:.:.|:..|:::.: .||:
Human    64 EEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDA 128

  Fly   138 VKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQRM 202
            .|.:|:|::..|...:..|....:.::.:.::|||:::|:..|...|.::.|....|.:|.:.|.
Human   129 RKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRK 193

  Fly   203 EVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAID----GLPELEEKLGQLDMNEV 263
            .|.||.|..:|.||..:.||.::|:||::...|:|:|:||..|:    ||.::||:|....::|.
Human   194 TVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEW 258

  Fly   264 AAKSLMK--EVDVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLS------DLFEMKTPQKIS 320
            .....:.  ||:|::|:|::|.:..|...|.::|:..:|::.:||||      |:|       ||
Human   259 TKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIF-------IS 316

  Fly   321 EARHKVFLNVTEFGCE-------VAPEAEVQPEVLKKNPDRKFFKADRPFVFAIRDRK--NVYFV 376
            :..||.|:.|.|.|.|       :|....:.||        :.|.||.||:|.||...  ::.|:
Human   317 KIVHKSFVEVNEEGTEAAAATAGIATFCMLMPE--------ENFTADHPFLFFIRHNSSGSILFL 373

  Fly   377 GHFVKP 382
            |.|..|
Human   374 GRFSSP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_610633.1	serpin42Dd-like_insects	13..382	CDD:381070	113/392 (29%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	115/394 (29%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		11/27 (41%)