DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn47C and Serpinh1

DIOPT Version :9

Sequence 1:	NP_001163116.1	Gene:	Spn47C / 36163	FlyBaseID:	FBgn0033574	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001104513.1	Gene:	Serpinh1 / 12406	MGIID:	88283	Length:	417	Species:	Mus musculus

Alignment Length:	393	Identity:	97/393 - (24%)
Similarity:	186/393 - (47%)	Gaps:	22/393 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASGGTTAPSLSASPIVFAR-------NLFRALNDEVPPVNMMVSPAGARSAMTLVFMGAGGKSAD 59
            |:...||..||:.....|.       :|::|:..:....|:::||....|::.||.:  |||:..
Mouse    26 AAAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSL--GGKATT 88

  Fly    60 ELRSKLILGVS--NKSEVAKQHAESWTDECSCAKKGVALRLVTRLYVNEEEKIRTDFNDMALEFF 122
            ..::|.:|...  ...||.....|......:...:.|..:|.:|||.........||...:.:.:
Mouse    89 ASQAKAVLSAEKLRDEEVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHY 153

  Fly   123 NAEAYSLNYLNPEDSVKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQ 187
            |.|...:|:.:...:::.:|:|..:.|...:..: |.:|..:|.: :|||::||:..|::.|..:
Mouse   154 NCEHSKINFRDKRSALQSINEWASQTTDGKLPEV-TKDVERTDGA-LLVNAMFFKPHWDEKFHHK 216

  Fly   188 LTQIDDFWINPRQRMEVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELE 252
            :.....|.:.....:.|:||.:.|.:.|.:.:|.|.|::::|......:::|::|..::.|..||
Mouse   217 MVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQMVEMPLAHKLSSLIILMPHHVEPLERLE 281

  Fly   253 EKLGQLDMNEVAAKSLMKEVDVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLSDLFEMKTPQ 317
            :.|.:..:.....|...|.|.:::||..:|.|.||:..|..:|:....|..:||||.:...|...
Mouse   282 KLLTKEQLKAWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLY 346

  Fly   318 KISEARHKVFLNVTEFGCEVAP-EAEVQPEVLKKNPDRKFFKADRPFVFAIRDRK--NVYFVGHF 379
            ..|......|    |:..|..| :.::......::|  |.|.||.||:|.:||.:  ::.|:|..
Mouse   347 LASVFHATAF----EWDTEGNPFDQDIYGREELRSP--KLFYADHPFIFLVRDNQSGSLLFIGRL 405

  Fly   380 VKP 382
            |:|
Mouse   406 VRP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_001163116.1	SERPIN	18..379	CDD:238101	90/372 (24%)
Serpinh1	NP_001104513.1	serpinH1_CBP1	35..416	CDD:381003	94/384 (24%)
Serpinh1	NP_001104513.1	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010