Protein Alignment Spn47C and SERPINA3

DIOPT Version :10

• Sequence 1: NP_610633.1
• Gene: Spn47C / 36163
• FlyBaseID: FBgn0033574
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 93/392 - (23%)
• Similarity: 183/392 - (46%)
• Gaps: 40/392 - (10%)

  Fly    11 LSASPIVFARNLFRALNDEVPPVNMMVSPAGARSAMTLVFMGAGGKSADELRSKLILGVSNKSEV 75
            |:::.:.||.:|::.|..:.|..|::.||....:|:..:.:||...:..|:...|...::..||.
Human    49 LASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEA 113

  Fly    76 ----AKQHAESWTDECSCAKKGVALRLVTRLYVNEEEKIRTDFNDMALEFFNAEAYSLNYLNPED 136
                :.||.....::.|   ..:.|.:...::|.|:..:...|.:.|...:.:||::.::.:...
Human   114 EIHQSFQHLLRTLNQSS---DELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAA 175

  Fly   137 SVKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQR 201
            :.|.:|.:::..|...:.:|.  :..:|.:.::|||.:||:|||...|..|.|....|:::.::.
Human   176 AKKLINDYVKNGTRGKITDLI--KDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKW 238

  Fly   202 MEVSMMR----QIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEKL------- 255
            :.|.||.    .|..||   .::|...:::|.: ..|.:.:.|||.. |.:.|:|..|
Human   239 VMVPMMSLHHLTIPYFR---DEELSCTVVELKY-TGNASALFILPDQ-DKMEEVEAMLLPETLKR 298

  Fly   256 --GQLDMNEVAAKSLMKEVDVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLSDLFEMKTPQK 318
              ..|:..|:.        ::.:|||.|....:|...|.::||...| ..:||||.:...:. ..
Human   299 WRDSLEFREIG--------ELYLPKFSISRDYNLNDILLQLGIEEAF-TSKADLSGITGARN-LA 353

  Fly   319 ISEARHKVFLNVTEFGCEVAPEAEVQPEVLKKNPD-RKFFKADRPFVFAI--RDRKNVYFVGHFV 380
            :|:..||..|:|.|.|.|.:....|:..:|....: |...:.:|||:..|  .|.:|::|:....
Human   354 VSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVT 418

  Fly   381 KP 382
            .|
Human   419 NP 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn47C	NP_610633.1	serpin42Dd-like_insects	13..382	CDD:381070	91/388 (23%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	93/392 (24%)
		RCL	369..394		5/24 (21%)
		O-glycosylated at one site	381..389		1/7 (14%)