DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and AVT3

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_012776.1	Gene:	AVT3 / 853710	SGDID:	S000001629	Length:	692	Species:	Saccharomyces cerevisiae

Alignment Length:	471	Identity:	106/471 - (22%)
Similarity:	200/471 - (42%)	Gaps:	61/471 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEPKSQDQAPNRDDPD---LQTEPLTIAQSITSFYMYNPYEKRSVEVPLTNCDAFISLLKCVIGT 62
            :..:.:::....::|:   |:||.   .|.::..:..:|::..:|:       |.:.|||..:||
Yeast   259 LSEEEEEEEETEEEPEEEALETES---TQLVSREHGRHPHKSSTVK-------AVLLLLKSFVGT 313

  Fly    63 GILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGP 127
            |:|.:|.||...|:.. :.:.:|...|::|...:.:....:     :|......:..||.|  ||
Yeast   314 GVLFLPKAFHNGGWGF-SALCLLSCALISYGCFVSLITTKD-----KVGVDGYGDMGRILY--GP 370

  Fly   128 KWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEIGDHYIE----RYNERYYVLVACLLL 188
            |        ..|.....:...|......|.||.:.|.:...:::..    ..:...|:....|:.
Yeast   371 K--------MKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYIFAQVLIF 427

  Fly   189 LPLFMIRRLKYLVPLNLISNFLLYAGFALI----MYYL-FNGLPNINDREMVTPPVEWIEFIAIA 248
            :||.:.|.:..|....||::..:..|...:    :||: .||:  .:|..::....:|..||..|
Yeast   428 VPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGV--ASDTMLMFNKADWSLFIGTA 490

  Fly   249 AFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNVHASITLNIP 313
            .|:...:|.::.::..|.||:.:......:...|..|.:|   .|::.|..||.:|...:.||.|
Yeast   491 IFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFIS---CGLLCYAAFGSDVKTVVLLNFP 552

  Fly   314 QDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDYEN----SEPRGRYRTLIEYV---VRLLFL 371
            ||...:..:::..|..|.||.||..|..|.::    ||    |...|:|...::::   .|...:
Yeast   553 QDTSYTLTVQLLYALAILLSTPLQLFPAIRIL----ENWTFPSNASGKYNPKVKWLKNYFRCAIV 613

  Fly   372 FLTGAVA-IGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWKLIRDILLILIGL 435
            .||..:| :|..:|.....|.|:|:...|..:.|.|:....:...|..|..      :||.||.:
Yeast   614 VLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSGTSRAR------LLLDLIVI 672

  Fly   436 IFGIVGCTVALMQLIR 451
            :||:........|.|:
Yeast   673 VFGVAVMAYTSWQTIK 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	88/373 (24%)
AVT3	NP_012776.1	Aa_trans	295..687	CDD:279788	99/429 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I928
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm9188
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
TreeFam	0	0.000	Not matched by this tool.
	7	6.860