DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and SLC38A1

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001265319.1	Gene:	SLC38A1 / 81539	HGNCID:	13447	Length:	503	Species:	Homo sapiens

Alignment Length:	518	Identity:	103/518 - (19%)
Similarity:	205/518 - (39%)	Gaps:	119/518 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PNRDDPDLQTEPLTIAQS--ITSFYMYNPYEKRSVEVPLTN-------CDAFI-----------S 54
            |..|:....:...|..::  |.|.::.:...:||    |||       ||.:|           :
Human    19 PEDDNISNDSNDFTEVENGQINSKFISDRESRRS----LTNSHLEKKKCDEYIPGTTSLGMSVFN 79

  Fly    55 LLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAV 119
            |...::|:|||.:..|...:|.::..|:...:.:|..|||:||:              :...|..
Human    80 LSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLL--------------ICSKETG 130

  Fly   120 RIAYEEGPKWINCFGRAAGFMTTCVLVFGQFLL----CTVYLVFVSKNFKEIGDHYI----ERYN 176
            .:.||:..:.:  ||....|     ::||...|    ..:..:|:.||.......::    |.::
Human   131 CMVYEKLGEQV--FGTTGKF-----VIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFS 188

  Fly   177 ERY------YVLVACLLLLPLFMIRRLKYLVPLNLISNFLL--YAGFALIMYYLFNGLP------ 227
            ..|      .|:|...::|||.:::.|.|   |...|.|.|  ...|.:::.|....:|
Human   189 AWYVDGRVLVVIVTFGIILPLCLLKNLGY---LGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPEL 250

  Fly   228 ------NINDREMVTPPVEWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFG---------- 276
                  |..:.:..||  :::.|.:...::|..:..     |.:.|| |.|.::.
Human   251 NSTISANSTNADTCTP--KYVTFNSKTVYALPTIAF-----AFVCHP-SVLPIYSELKDRSQKKM 307

  Fly   277 --VLNLAVLFILLSNMFF--GIIGYWRFGDNVHASITLNI-PQDEILSQFIKVFIASGIFLSYPL 336
              |.|::  |..:..|:|  .|.||..|.|||.:.:.... .:|:||...:::.:...:.|:.|:
Human   308 QMVSNIS--FFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPV 370

  Fly   337 NGFVVITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNL 401
            ..|.|.:.:|    ....:.::......||..:.|.:...:.|.:|::..:..:.|..|.:.|..
Human   371 LFFTVRSSLF----ELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIF 431

  Fly   402 LCPALIDVFLNYNVGYG----RLMWKLIRDILLILIGLIFGIVGCTVALMQLIRDFQLTLNSM 460
            :.|:  .::|......|    :.:|        :.:.|.|.:..|.::...::....|:||.:
Human   432 ILPS--SLYLKITDQDGDKGTQRIW--------LFLFLQFPVQPCWLSECIILLPAALSLNML 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	83/410 (20%)
SLC38A1	NP_001265319.1	SLC5-6-like_sbd	69..480	CDD:382020	87/458 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750