DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and Slc38a3

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001186146.1	Gene:	Slc38a3 / 76257	MGIID:	1923507	Length:	505	Species:	Mus musculus

Alignment Length:	496	Identity:	108/496 - (21%)
Similarity:	188/496 - (37%)	Gaps:	119/496 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LQTEP-----LTIAQSITSFYMYNPYEKRSVEVPLTNCDAFISLLKCVIGTGILAMPLAFRCSGF 76
            ||..|     .|..:..|||.|                 :..:|...::|:|||.:..|...:|.
Mouse    48 LQKSPSKEPHFTDFEGKTSFGM-----------------SVFNLSNAIMGSGILGLAYAMANTGI 95

  Fly    77 VMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEE-GPKWINCFGRAAGFM 140
            ::...:...:.:|.:||||||:             :.|....:| |||: |.:.....|:.|..:
Mouse    96 ILFLFLLTAVALLSSYSIHLLL-------------KSSGIVGIR-AYEQLGYRAFGTPGKLAAAL 146

  Fly   141 TTCVLVFGQFLLCTVYLVFVSKNFKEIGDHYIER-------YNERYY--VLVACLLLLPLFMIRR 196
            ...:...|..   :.||..:......:...::..       |.:..|  :||:..::|||.::|:
Mouse   147 AITLQNIGAM---SSYLYIIKSELPLVIQTFLNLEKPASVWYMDGNYLVILVSVTIILPLALMRQ 208

  Fly   197 LKYL-----VPLNLISNFL---LYAGFAL---IMYYLFNGLPNINDREMVT----------PPVE 240
            |.||     ..|:.:..||   :|..|.:   :.:.|.|...|.:  .||.          |...
Mouse   209 LGYLGYSSGFSLSCMVFFLIAVIYKKFQVPCPLAHNLANATGNFS--HMVVAEEKAQLQGEPDTA 271

  Fly   241 WIEFIAIAAFSL---TAVGSMLVVEAHMAHPQ---SYLGL----------FGVLNLAVLFILLSN 289
            ...|...:.|:|   ||....::..|.:.||:   .|..|          ...|::||:::
Mouse   272 AEAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKRKMQHISNLSIAVMYV---- 332

  Fly   290 MFF--GIIGYWRFGDNVHASIT---LNIPQDEILSQFIKVFIASGIFLSYPLNGFVV---ITVMF 346
            |:|  .:.||..|.|.|.:.:.   ..:...::|...::|.:...:.|:.|:..|.|   |..|.
Mouse   333 MYFLAALFGYLTFYDGVESELLHTYSKVDPFDVLILCVRVAVLIAVTLTVPIVLFPVRRAIQQML 397

  Fly   347 SDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFL 411
              ::|.|    :..|...::....|.....:.|..||:..:..:.||.|...|..:.||:.
Mouse   398 --FQNQE----FSWLRHVLIATGLLTCINLLVIFAPNILGIFGIIGATSAPCLIFIFPAIF---- 452

  Fly   412 NYNVGYGRLM---WKLIRDILLILIGLIFGIVGCTVALMQL 449
                 |.|:|   .:..|....|| .|.|..||..:..|.|
Mouse   453 -----YFRIMPTDKEPARSTPKIL-ALCFAAVGFLLMTMSL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	88/411 (21%)
Slc38a3	NP_001186146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..48		108/496 (22%)
Slc38a3	NP_001186146.1	Aa_trans	63..492	CDD:279788	104/481 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840