DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and Slc38a10

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	XP_006534347.1	Gene:	Slc38a10 / 72055	MGIID:	1919305	Length:	1111	Species:	Mus musculus

Alignment Length:	399	Identity:	75/399 - (18%)
Similarity:	155/399 - (38%)	Gaps:	92/399 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIH---LLIADMTECCRRRRVPQVSM 115
            :::..::|..:|.||..|:..|.|:|.    ||::..::..|   :.:.......:||....::
Mouse    14 NVVNSIVGVSVLTMPFCFKQCGIVLGA----LLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLA- 73

  Fly   116 PEAVRIAYEEGPKWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEIGDHY--------I 172
                          .:.:|:|...:....::......|..:.|.:.    ::|.::        :
Mouse    74 --------------FHAYGKAGKMLVETSMIGLMLGSCITFYVVIG----DLGSNFFAPLLGLQV 120

  Fly   173 ERYNERYYVL--VACLLLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLF----------NG 225
            .| ..|.::|  |:..::|||.:.|        |::::...::..||:.|.:|          :|
Mouse   121 TR-TVRVFLLFAVSLFIVLPLSLQR--------NMMASIQSFSAMALLFYTVFMFVIVLSSLKHG 176

  Fly   226 LPNINDREMVTPPVEW---IEFIAIAAFSLTAVGSMLVVEAHMAHP--QSYLGLF-GVLNLAVLF 284
            |.:......|: .:.|   ...:.|...|......:|.....:..|  ::...:| ..||:...|
Mouse   177 LFSGQWLRQVS-YIRWEGVFRCVPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTAF 240

  Fly   285 ILLSNMFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFLSYP---------LNGFV 340
            .::    .|..||..|.|....::.::.|.:.: ::.|:|.....:.:.:|         ||
Mouse   241 YVM----VGFFGYVSFTDATTGNVLIHFPSNPV-TEMIRVGFVMSVAVGFPMMILPCRQALN--- 297

  Fly   341 VITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIG-------VPNLAALTELEGAFSLSN 398
              |::|   |..:..|.: ....|:..|.|..||.:|..|       :||:..:....||...|.
Mouse   298 --TLLF---EQQQKDGTF-AAGGYMPPLRFKVLTLSVVFGTMVGGVMIPNVETILGFTGATMGSL 356

  Fly   399 LNLLCPALI 407
            :..:|||||
Mouse   357 ICFICPALI 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	73/397 (18%)
Slc38a10	XP_006534347.1	SLC5-6-like_sbd	6..381	CDD:382020	75/399 (19%)
		PTZ00121	<407..789	CDD:173412
		PTZ00449	<731..>991	CDD:185628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810