DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and Slc38a2

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_780330.2	Gene:	Slc38a2 / 67760	MGIID:	1915010	Length:	504	Species:	Mus musculus

Alignment Length:	463	Identity:	89/463 - (19%)
Similarity:	169/463 - (36%)	Gaps:	108/463 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEA 118
            :|...::|:|||.:..|...:|..:..::...:.|...||:|||:.              :..|.
Mouse    79 NLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLK--------------TANEG 129

  Fly   119 VRIAYEE-GPKWINCFGR--AAGFMT-TCVLVFGQFLLCTVY-LVFVSKNFKEIGD----HYIER 174
            ..:.||: |.|.....|:  |:|.:| ..:.....:|....| |..|.|....|.|    .|:
Mouse   130 GSLLYEQLGHKAYGLAGKLAASGSITMQNIGAMSSYLFIVKYELPLVIKALMNIEDTNGLWYL-- 192

  Fly   175 YNERYYV-LVACLLLLPLFMIRRLKYL----------------------------VPLNLISNFL 210
             |..|.| ||:.:|:|||.::|.|.||                            |...|::|..
Mouse   193 -NGDYLVLLVSLVLILPLSLLRNLGYLGYTSGLSLLCMIFFLIVVICKKFQIPCPVEAALVANET 256

  Fly   211 LYAGF---ALIM-------------YYLFNGLPNINDREMVTPPVEWIEFIAIAAFSLTAVGSML 259
            :...|   ||.:             |::||.              :.:..:.|..||.....::|
Mouse   257 VNGTFTQAALALAFNSTADDACRPRYFIFNS--------------QTVYAVPILTFSFVCHPAVL 307

  Fly   260 VVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNVHASIT---LNIPQDEILSQF 321
            .:...: ..:|...:..|..::...:.|..:...:.||..|..:|.:.:.   ..|...:||...
Mouse   308 PIYEEL-KSRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYGHVESELLHTYSEIVGTDILLLV 371

  Fly   322 IKVFIASGIFLSYPLNGFVVITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAA 386
            :::.:...:.|:.|:   |:..:..|......|...:..|...::.:..|..|..:.|.||.:..
Mouse   372 VRLAVLVAVTLTVPV---VIFPIRSSVTHLLCPTKEFSWLRHSIITVTILSFTNLLVIFVPTIRD 433

  Fly   387 LTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWK-------LIRDILLILIGLIFGIVGCTV 444
            :....||.:.:.|..:.|:..         |.:|:.|       .|..:..:|.|::..|....:
Mouse   434 IFGFIGASAAAMLIFILPSAF---------YIKLVKKEPMRSVQKIGALCFLLSGIVVMIGSMGL 489

  Fly   445 ALMQLIRD 452
            .::..:.|
Mouse   490 IVLDWVHD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	81/409 (20%)
Slc38a2	NP_780330.2	Regulates protein turnover upon amino acid deprivation. /evidence=ECO:0000250	1..96		5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		SLC5-6-like_sbd	69..491	CDD:382020	88/455 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840