DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and slc36a4

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	XP_002664741.3	Gene:	slc36a4 / 504109	ZFINID:	ZDB-GENE-050309-239	Length:	488	Species:	Danio rerio

Alignment Length:	443	Identity:	114/443 - (25%)
Similarity:	206/443 - (46%)	Gaps:	41/443 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EKRSVEVP--LTNCDAFISLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIAD 100
            ::.|..:|  :|.....:.|||..||||:|.:|||.:.:|.|:|.|..:|:.::..:.:|:|:..
Zfish    33 DEDSKHLPQGITFTQTLLHLLKGNIGTGLLGLPLAVKNAGIVLGPVSLVLMGVVCVHCMHILVNC 97

  Fly   101 MTECCRRRRVPQVSMPEAVRIAYEEGPKWINCFGRAAGF---MTTCVLVFGQFLLCTVYLVFVSK 162
            ..:...|.:...:...|.|..|.|....  .|..|:|.|   :....||..|...|:||.||:::
Zfish    98 SHQLSERLKRSPLGYSETVAAAMELSSS--QCLRRSAHFGRHLVNFFLVLTQLGFCSVYFVFLAE 160

  Fly   163 NFKEI--GDHYIE--------------------RYNERYYVLVACLLLLPLFMIRRLKYLVPLNL 205
            |.|::  |.|...                    ..:.|.|::.....::.|..||.|:.:..|:.
Zfish   161 NIKQVMEGTHMNSTAETVLLSSNSSEASVASSVAIDLRLYMVFLLPFIIVLTFIRDLRNMAALSA 225

  Fly   206 ISNFLLYAGFALIMYYLFNGLPNINDREMVTPPVEWIE---FIAIAAFSLTAVGSMLVVEAHMAH 267
            |:|..:......|..|:.|   :::|...:.....|.:   |...|.|:...:|.:|.:|..|..
Zfish   226 IANLCMAISLIFIFSYILN---DLSDPRRLPYASTWRKFPFFFGTAIFAFEGIGVVLPLENQMRE 287

  Fly   268 PQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFL 332
            |:.:.   ..||:.:.||::..:....:||.||.|::..|||||:|.|...:|.:||..:.|:|:
Zfish   288 PKRFP---QALNIGMGFIIVLYVTLATLGYLRFRDDIKGSITLNLPHDSWSNQLVKVLYSFGVFV 349

  Fly   333 SYPLNGFVVITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLS 397
            |:.:..||...::.... ....|..:|.:.:..:|.|.:.||...|:.:|.|..:..|.||.|.|
Zfish   350 SFAVQFFVPAEILLPPM-CERVRKSWRRVADLSLRALLVCLTCVTAVLIPRLDLVISLVGAVSSS 413

  Fly   398 NLNLLCPALIDVFLNYNVGYGRLMWKLIRDILLILIGLIFGIVGCTVALMQLI 450
            .|.|:.|.|:::....:.....::  |::||.:..:|.|..:.|..|.:.::|
Zfish   414 ALALVFPPLVELIAFPSQPPPPML--LLKDISIAALGFIGFLTGTYVTVEEII 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	102/384 (27%)
slc36a4	XP_002664741.3	SLC5-6-like_sbd	42..460	CDD:294310	111/428 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.960