DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and slc38a4

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001005944.2	Gene:	slc38a4 / 449771	ZFINID:	ZDB-GENE-041010-14	Length:	538	Species:	Danio rerio

Alignment Length:	497	Identity:	101/497 - (20%)
Similarity:	186/497 - (37%)	Gaps:	144/497 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEA 118
            :|...::|:|||.:..|...:|.::..::.:.:.||..||:|||:              |:..|.
Zfish    80 NLSNAIMGSGILGLSFAMANTGIILFVILLLGVAILSLYSVHLLL--------------VTAKEG 130

  Fly   119 VRIAYEE-GPKWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEI-----------GDHY 171
            ..:.||: |.:.....|:.|.|.:..:...|..   :.||..|.....|:           |:.|
Zfish   131 GSLIYEKLGERAFGWPGKMAAFGSITLQNIGAM---SSYLFIVKYELPEVIRAFLGLEESSGEWY 192

  Fly   172 IERYNERY-YVLVACLLLLPLFMIRRLKYL--------------------------VPLNLI--- 206
            :   |..| .|||:..::|||.:::.|.||                          .||...
Zfish   193 L---NGNYVVVLVSIGIILPLSLLKNLGYLGYTSGFSLSCMVFFLGVLIYKKTILPCPLPFFFEH 254

  Fly   207 -SNFLLYAGFALIMYYLFNG---------LPNIND------------------REMVTPPV---- 239
             ||..:....|:.:|.|.|.         ..|..|                  ::|.||..
Zfish   255 GSNVSINGSDAIALYGLHNASALAYMSETAANAVDPHTPLHDSVQFSAHPEDHQDMCTPKYFIFN 319

  Fly   240 -EWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDN 303
             :.:..:.|.||:......:|.:.:.:.: :|...:..|.||::|.:|:..:...:.||..|.|:
Zfish   320 SQTVYTVPILAFAFVCHPEVLPIYSELKN-RSRRRMQSVSNLSILAMLVMYLLSALFGYLTFYDH 383

  Fly   304 VHASITLNIPQDEILSQFIKVF------------IASGIFLSYPLNGF----VVITVMFSDYENS 352
            |.|         |:|..|.||:            :.:.:.|:.|:..|    .|||:.|:..|.|
Zfish   384 VEA---------ELLHTFTKVYKFDTMLLMVRLAVLTAVTLTVPIVLFPIRSSVITLCFAGKEFS 439

  Fly   353 EPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGY 417
            ..|       .:::....|.....:.|.||.:..:....|:.:.:.|..:.||..         |
Zfish   440 WIR-------HFLIAAAILAFNNLLVIFVPTIRDIFGFIGSSAATMLIFILPAAF---------Y 488

  Fly   418 GRLMWKL-------IRDILLILIGLIFGIVGCTVALMQLIRD 452
            .||:..|       |..::.:::|:.|.|...::.::..|.:
Zfish   489 LRLVKSLPMKSPQKISALIFLVVGIFFMIGSLSLIVLDWIHN 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	92/443 (21%)
slc38a4	NP_001005944.2	DUF4404	3..90	CDD:291055	2/9 (22%)
		SdaC	68..520	CDD:223884	100/485 (21%)
		SLC5-6-like_sbd	72..525	CDD:294310	100/490 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594575
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750