DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polyph and path

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001261634.1	Gene:	path / 39106	FlyBaseID:	FBgn0036007	Length:	471	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	131/431 - (30%)
Similarity:	234/431 - (54%)	Gaps:	24/431 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YNPYEKRSVEVPLTNCDAFISLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLI 98
            ::|:..|....|.|:.:....|||..:|||||.||.||.|||.:||...:|....:.|:..::|:
  Fly    46 FDPFALRDNPHPTTDNETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLV 110

  Fly    99 ADMTECCRRRRVPQVSMPEAVRIAYEEGPKWINCFGRAAGFMTTCVLVFGQFL----LCTVYLVF 159
            ....:...|.|..:::..|....|:::||||...|...|.|.    ::||.||    .|:||.|.
  Fly   111 KCGHKLYYRTRRTKMTFAEIAEAAFQKGPKWCRGFAPVAKFS----ILFGLFLTYFGTCSVYTVI 171

  Fly   160 VSKNFKEIGDHYI-ERYNERYYVLVACLLLLPLFMIR---RLKYLVPLNLISNFLLYAGFALIMY 220
            |:.||:::..::. ...:.|   ::.|::|:||.:|.   .||||.|:::::|..:..|..:..|
  Fly   172 VASNFEQLISYWTGTAVSLR---MLICIMLVPLILIAWVPNLKYLAPVSMVANVFMGLGLGITFY 233

  Fly   221 YLFNGLPNINDREMV---TPPVEWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAV 282
            ||...||.:.:||.|   |.|    :|.:|..|::.|:|.::.:|.:|..|||:||:.|||:..:
  Fly   234 YLVQDLPPVEERESVVWSTLP----QFFSITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQGM 294

  Fly   283 LFILLSNMFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFS 347
            ..:.|..|..|.:||.|:|.....|||||:|.:|..:|.:||.|:..::.::.|..||.:.:::.
  Fly   295 SGVTLIYMLLGFLGYLRYGSATGESITLNLPIEEWPAQTVKVLISLAVYCTFGLQFFVCLEIIWD 359

  Fly   348 DYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLN 412
            ..:  |...:..||:.||:|.:.:.....:|:.||.:.....|.|||..|.|.|:.|.:|::.::
  Fly   360 GIK--EKCKKRPTLVNYVLRTVLVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIFPVVIELIVH 422

  Fly   413 YNVGYGRLMWKLIRDILLILIGLIFGIVGCTVALMQLIRDF 453
            :..|:|:..|.|.::.::.|.|:...:.|...|:..:::.:
  Fly   423 WESGFGKYNWILWKNAIITLCGIGALVFGTQAAIKDIVKAY 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	118/367 (32%)
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	128/412 (31%)
path	NP_001261634.1	SdaC	67..445	CDD:223884	124/390 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I1306
eggNOG	1	0.900	-	-		E1_COG0814
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1622
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm1178
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
	10	9.980