DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and Slc36a4

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001101597.1	Gene:	Slc36a4 / 315439	RGDID:	1311528	Length:	500	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	115/445 - (25%)
Similarity:	213/445 - (47%)	Gaps:	56/445 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAV 119
            |||..||||:|.:|||.:.:|.|:|.:..:.:.|:..:.:|:|:......|:|.:...:...:.|
  Rat    65 LLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKSTLGYSDTV 129

  Fly   120 RIAYEEGPKWINCFGRAAGFMTTCV---LVFGQFLLCTVYLVFVSKNFKEIGDHYIE-------- 173
            ..|.|..| | :|..|.|.:..:.|   ||..|...|:||:||:::|.|::.:..:|
  Rat   130 SFAMEASP-W-SCLQRQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGLLETTVVVSNS 192

  Fly   174 ----------RYNERYYVLVACLLLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFNGLPN 228
                      ..:.|.|:|....||:.|..||.||.|..|:.::|..:.|...:|..|:...:|:
  Rat   193 SDLSQVCERRSVDLRVYMLCFLPLLILLVFIRELKSLFVLSFLANISMAASLVIIYQYVVRSMPD 257

  Fly   229 INDREMVTPPVEWIEFIAIAAFSLTAVGSMLVVEAHMAH----PQSYLGLFGVLNLAVLFILLSN 289
            .::..:|....::..|...|.|:...:|.:|.:|..|..    ||:       ||:.:..:.:..
  Rat   258 PHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRESKRFPQA-------LNIGMAIVTVLY 315

  Fly   290 MFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDYENSEP 354
            :....:||..|.|.:..|||||:|||..|.|.:|:..:.|||::|.:..:|...::.... .:..
  Rat   316 ISLATLGYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPAV-TARL 379

  Fly   355 RGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFL----NYNV 415
            ..:::.:.::.:|.|.:.:|.|.|:.:|.|..:....||.|.|.|.|:.|.|:::..    :|||
  Rat   380 HAKWKCICDFGIRSLLVSITCAGAVLIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKDHYNV 444

  Fly   416 GYGRLMWKLIRDILLILIGLIFGIVGCTVALMQLI-----------RDFQLTLNS 459
                  |.::::|.:...|.:..::|..|.:.::|           :...|.:||
  Rat   445 ------WMVLKNISIAFTGFVGFLLGTYVTVEEIIYPTTAVADGASQSLSLNVNS 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	102/376 (27%)
Slc36a4	NP_001101597.1	SLC5-6-like_sbd	54..469	CDD:294310	111/419 (26%)
Slc36a4	NP_001101597.1	PotE	<223..477	CDD:223605	67/267 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860