DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polyph and Slc38a9

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001030328.1	Gene:	Slc38a9 / 310091	RGDID:	1311881	Length:	559	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	98/514 - (19%)
Similarity:	175/514 - (34%)	Gaps:	168/514 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YMYNP-------------YEKRSVEVPLTNCDAFISLLKCVIGTGILAMPLAFRCSGFVMGTVMS 83
            |:|:|             |.|.      |:......:...::||.||::|...:.:||..|..:.
  Rat    95 YVYSPLGSAYKLKSYTEGYRKN------TSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVI 153

  Fly    84 ILLMILLTYSIHLLIADMTECCRR--RRVPQVSMPEAVRIAYEEGPK-WINCFGRAAGFMTTCVL 145
            :|:.:|..|           ||.|  :....:...:.....|.:..| :...||:.:..:.:.|.
  Rat   154 VLMGLLTLY-----------CCYRVVKSRSMIVTSDTTTWEYPDVCKHYFGSFGQWSSLLFSLVS 207

  Fly   146 VFGQFLLCTVYLVFVSKNFKEIGD---HYIERYNERYYVL-------VACL-------------- 186
            :.|..:   ||.|.:|......|.   ::|...|:...||       |.|.
  Rat   208 LIGAMI---VYWVLMSNFLFNTGKFIFNFIHHINDTDTVLSTNNSSPVICPSAGSGHPDNSSMIF 269

  Fly   187 --------------------------LLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFNG 225
                                      |||||...:...:....|::       |...::|.:|
  Rat   270 YNSDTEVRLFERWWDKSKTVPFYLIGLLLPLLNFKSPSFFSKFNIL-------GTVSVLYLIF-- 325

  Fly   226 LPNINDREMVTPPVEWIEFIAIA---AFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNL------- 280
                    :||     ::.|.:.   .|...|.....|.|.....||    |.|||.|
  Rat   326 --------IVT-----LKAIRLGFHLEFHWFAPTEFFVPEIRAQFPQ----LTGVLTLAFFIHNC 373

  Fly   281 --------------------AVLFILLSNMFFGIIGYWRF------GDNVHASITLNIPQDEILS 319
                                |.:.:.|:.::.|::.:..|      .|.:..:...|.|..:.||
  Rat   374 IITLLKNNKNQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLPKDCIEQNFLDNFPSSDTLS 438

  Fly   320 QFIKVFIASGIFLSYPLNGFV----VITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGA---V 377
            ...::.:...:...|||.|::    ::..:|.|.        |.::  :.|.:|.|.:.||   :
  Rat   439 FIARICLLFQMMTVYPLLGYLARVQLLGHIFGDI--------YPSI--FHVLILNLIIVGAGVTM 493

  Fly   378 AIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMW-KLIRDILLILIGL 435
            |...||:..:....||........:.|:||.:...:.  ..||.| ||:..|::|::||
  Rat   494 ACFYPNIGGIIRYSGAACGLAFVFIYPSLIYILSQHQ--EERLTWPKLVFHIIIIILGL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	81/452 (18%)
Slc38a9	NP_001030328.1	SLC5-6-like_sbd	114..555	CDD:382020	94/495 (19%)
Slc38a9	NP_001030328.1	Important for arginine binding and amino acid transport. /evidence=ECO:0000250\|UniProtKB:Q08BA4	128..133		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830