DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and Slc38a6

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001013117.1	Gene:	Slc38a6 / 299139	RGDID:	1310330	Length:	457	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	100/480 - (20%)
Similarity:	192/480 - (40%)	Gaps:	98/480 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PDLQTEPLTIAQSITSFYMYNPYEKRSVEVPLTNCDAFISLLKCVIGTGILAMPLAFRCSGFVMG 79
            |.|..||.....|..||.:                 :..:::..::|:|||.:......:|.:..
  Rat    32 PLLSNEPRRQGSSGASFGL-----------------SVFNVMNAIMGSGILGLAYVMANTGILGF 79

  Fly    80 TVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGPKWINCFGRAAGFMTTCV 144
            :.:.:|:.:|.:||:|||:|    .|....|          .:||:       .|..|..:...|
  Rat    80 SFLLLLVALLASYSVHLLLA----MCIHTAV----------TSYED-------LGLFAFGLPGKV 123

  Fly   145 LVFGQFLLCTV-----YLVFVSKN----FKEI--GDH----YIERYNERYYVLVACLLLLPLFMI 194
            :|.|..::..:     ||:.:...    ..|:  .||    |::  .:...:::...::.||.::
  Rat   124 VVAGTIIIQNIGAMSSYLLIIKTELPAAISEVLPSDHSGAWYLD--GQMLLIIICVGIVFPLSLL 186

  Fly   195 RRLKYLVPLNLISNFLLYAGFALIMYY------------LFNGLPNI-NDREMVTPPV-----EW 241
            .::.:|...:.:| |.....|||::..            ..|.:..| |..:...|.:     |.
  Rat   187 PKIGFLGYTSSLS-FFFMVFFALVVVIKKWAVPCPLTLNCINAVFQISNATDDCKPKLFHFSKES 250

  Fly   242 IEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNVHA 306
            :..|...|||.....|:|.:...:..| |...:..|.|.|:....|......:.||..|.|.|.:
  Rat   251 VYAIPTMAFSFLCHTSVLPIYCELRSP-SKKRMQNVTNTAIALSFLVYFVSALFGYLTFYDKVES 314

  Fly   307 SI----TLNIPQDEILSQFIKVFIASGIFLSYPLNGF----VVITVMFSDYENSEPRGRYRTLIE 363
            .:    :..:|.|..: ..:|:.|...:.|:.||..|    .::.::||:|..|..|....||..
  Rat   315 ELLQGYSKYLPHDAAV-MAVKLCILFAVLLTVPLIHFPARKALMMILFSNYPFSWIRHSLTTLAL 378

  Fly   364 YVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWKLIRDI 428
            .::.:|       :||.||::..:..:.||.:.:.|..:.|.|..:.|:..   ..|.||.:..:
  Rat   379 NIIIVL-------LAIYVPDIRNVFGVVGASTSTCLIFVFPGLFYLKLSRE---DFLSWKKLGAL 433

  Fly   429 LLILIGLIFGIVGCTVALMQLIRDF 453
            .|:..|.:.|    :.:|:.:|.|:
  Rat   434 SLLSTGTVVG----SFSLVLIILDW 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	82/397 (21%)
Slc38a6	NP_001013117.1	SLC5-6-like_sbd	45..452	CDD:294310	93/463 (20%)
Slc38a6	NP_001013117.1	SdaC	45..447	CDD:223884	92/458 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352559
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840