DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and Slc38a7

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_766346.1	Gene:	Slc38a7 / 234595	MGIID:	2679005	Length:	463	Species:	Mus musculus

Alignment Length:	497	Identity:	107/497 - (21%)
Similarity:	187/497 - (37%)	Gaps:	118/497 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PKSQDQAPNRDDPDLQTEPLTIAQSITSFYMYNPYEKRSVEVPLTNCDAFISLLKCVIGTGILAM 67
            |||:.:| :..|||..|         ||                |....||.:..| :|.|:|..
Mouse    35 PKSEGEA-SPGDPDSGT---------TS----------------TLGAVFIVVNAC-LGAGLLNF 72

  Fly    68 PLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGPKWINC 132
            |.||..:|.|...:...:.|::...|..:::|..::....|...:|              .|..|
Mouse    73 PAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQASNERTYQEV--------------VWAVC 123

  Fly   133 FGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEI---------GDHYIERYNERYYV--LVACL 186
             |:..|.:....:....|..|..:|:.:.....:|         |......|.:|.:.  |.|.|
Mouse   124 -GKLTGVLCEVAIAVYTFGTCIAFLIIIGDQQDKIIAVMSKEPDGASGSPWYTDRKFTISLTAFL 187

  Fly   187 LLLPLFMIRRL---KYLVPLNLISNFLLYAGFALIMYYLFNGLPNINDREM-----VTPPVEWIE 243
            .:|||.:.:.:   ||...|:::..:  |....:|:.|::      .|:||     :|.|..|:.
Mouse   188 FILPLSIPKEIGFQKYASFLSVVGTW--YVTAIIIIKYIW------PDKEMRPGDILTRPASWMA 244

  Fly   244 -FIAI--AAFSLTAVGSMLVVEAHMAHPQ-SYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNV 304
             |.|:  ..|......|.:.|...|..|: ...|  ||:..|::..|...|..||.|:..||..|
Mouse   245 VFNAMPTICFGFQCHVSSVPVFNSMRQPEVKTWG--GVVTAAMVIALAVYMGTGICGFLTFGAAV 307

  Fly   305 HASITLNIPQDEILSQFIKVFIASGIFLSYPLNGF---VVITVMFSDY-----ENSEPRGRYRTL 361
            ...:..:.|.:::.....:.||...:..|||:..|   .|:..::..|     |....|.|.|.:
Mouse   308 DPDVLRSYPSEDVAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYKGMPVEEDVGRERRRRV 372

  Fly   362 IEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFS----------------LSNLNLLCPALIDVF 410
            ::   .|::..||..:|:.:|::..:..:.|..:                ||.:..:.||
Mouse   373 LQ---TLVWFLLTLLLALFIPDIGKVISVIGGLAACFIFIFPGLCLIQAKLSEMEEVKPA----- 429

  Fly   411 LNYNVGYGRLMWKLIR-DILLILIG-LIFGIVGCTVALMQLI 450
                     ..|.|:. .:||:.:| .|||........:.|:
Mouse   430 ---------SWWALVSYGVLLVTLGAFIFGQTTANAIFVDLL 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	87/403 (22%)
Slc38a7	NP_766346.1	SLC5-6-like_sbd	49..458	CDD:382020	99/476 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4217
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.700