DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and Slc38a1

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_620187.1	Gene:	Slc38a1 / 170567	RGDID:	69645	Length:	485	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	101/495 - (20%)
Similarity:	201/495 - (40%)	Gaps:	99/495 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PNRDDPDLQTEPLTIAQS--ITSFYMYNPYEKRSVEVPLTN-------CDAFI-----------S 54
            |..|:....:...|..::  |.|.::.:...:||    |||       ||.:|           :
  Rat    19 PEDDNVSNDSNDFTEVENGQINSKFISDRESRRS----LTNSHLEKRKCDEYIPGTTSLGMSVFN 79

  Fly    55 LLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAV 119
            |...::|:|||.:..|...:|.::..::...:.:|..|||:||:              :...|..
  Rat    80 LSNAIMGSGILGLAFALANTGILLFLILLTSVTLLSIYSINLLL--------------ICSKETG 130

  Fly   120 RIAYEE-GPKWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKN-----FKEI-GDHYIERYNE 177
            .:.||: |.:.....|:...|..|.:...|..|   .|| |:.||     .|.: |:.  |.::.
  Rat   131 CMVYEKLGEQVFGTTGKLVIFGATSLQNTGAML---SYL-FIVKNELPSAIKSLMGEE--ETFSA 189

  Fly   178 RY------YVLVACLLLLPLFMIRRLKYL-----VPLNLISNFLLYAGFALIMYYLFNGLPN--- 228
            .|      .|:|...::|||.:::.|.||     ..|:.:..||:...:........||..|
  Rat   190 WYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCMNGEQNSTV 254

  Fly   229 -INDREMVTPPVEWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFG------------VLNL 280
             .|..:..||  :::.|.:...::|..:..     |.:.|| |.|.::.            |.|:
  Rat   255 SANVTDACTP--KYVTFNSKTVYALPTIAF-----AFVCHP-SVLPIYSELKDRSQKKMQMVSNI 311

  Fly   281 AVLFILLSNMFF--GIIGYWRFGDNVHASITLNIPQD--EILSQFIKVFIASGIFLSYPLNGFVV 341
            :  |..:..|:|  .|.||..|.:.|.:.: |:..|.  :||...:::.:...:.|:.|:..|.|
  Rat   312 S--FFAMFVMYFLTAIFGYLTFYEKVQSDL-LHKYQSTGDILILTVRLAVIVAVILTVPVLFFTV 373

  Fly   342 ITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPAL 406
            .:.:|    ....:.::......:|.::.|.:...:.|.:|::..:..:.|..|.:.|..:.|:
  Rat   374 RSSLF----ELAKKTKFHLCRHVLVTIILLVIINLLVIFIPSMKDIFGVVGVTSANMLIFILPS- 433

  Fly   407 IDVFLNYNVGYGRLMWKLIRDILLILIGLIFGIVGCTVAL 446
             .::|......|....:.|...|.:.:|::|.::...:.:
  Rat   434 -SLYLKITNQDGDKNTQRIWAALFLALGVLFSLISIPLVI 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	84/405 (21%)
Slc38a1	NP_620187.1	SLC5-6-like_sbd	69..472	CDD:382020	88/439 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750