DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and Slc36a1

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_569099.1	Gene:	Slc36a1 / 155205	RGDID:	619801	Length:	475	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	126/475 - (26%)
Similarity:	221/475 - (46%)	Gaps:	44/475 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SQDQAPNRDDPDLQTEPLTIAQS----ITSFYMYNP--YEKRSVEVPLTNCDAFISLLKCVIGTG 63
            |..:..|.|..|..:..::..:|    :.||   :|  |::......:|.....|.|||..||||
  Rat     2 STQRLRNEDYHDYSSTDVSPEESPSEGLGSF---SPGSYQRLGENSSMTWFQTLIHLLKGNIGTG 63

  Fly    64 ILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGPK 128
            :|.:|||.:.:|.::|.:..:::.|:..:.:.:|:......|||...|.:...:.|....|..|.
  Rat    64 LLGLPLAVKNAGLLLGPLSLLVIGIVAVHCMGILVKCAHHLCRRLNKPFLDYGDTVMYGLECSPS 128

  Fly   129 -WINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEIGDHYIERYN---------------- 176
             ||.........:....||..|...|.||.||::.|||::    ||..|
  Rat   129 TWIRNHSHWGRRIVDFFLVVTQLGFCCVYFVFLADNFKQV----IEAANGTTTNCNNNETVILTP 189

  Fly   177 ---ERYYVLVACLLLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFNGLPNINDREMVTPP 238
               .|.|:|.....|:.|..||.|:.|...:|::|..::....:|..::...:|:.:...:|.|.
  Rat   190 TMDSRLYMLTFLPFLVLLSFIRNLRILSIFSLLANISMFVSLIMIYQFIVQRIPDPSHLPLVAPW 254

  Fly   239 VEWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSY-LGLF-GVLNLAVLFILLSNMFFGIIGYWRFG 301
            ..:..|...|.|:...:|.:|.:|..|...|.: |.|: |:..:.||:|.|     |.:||.:||
  Rat   255 KTYPLFFGTAIFAFEGIGVVLPLENKMKDSQKFPLILYLGMAIITVLYISL-----GSLGYLQFG 314

  Fly   302 DNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDYENSEPRGRYRTLIEYVV 366
            .::..|||||:| :..|.|.:|:..:.|||.:|.|..:|...::.....:..|. |:..:::...
  Rat   315 ADIKGSITLNLP-NCWLYQSVKLLYSIGIFFTYALQFYVAAEIIIPAIVSRVPE-RFELVVDLSA 377

  Fly   367 RLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWKLIRDILLI 431
            |...:.:|..:|:.:|.|..:..|.|:.|.|.|.|:.|.|::|...|..|...|  .:.:|.|:.
  Rat   378 RTAMVCVTCVLAVLIPRLDLVISLVGSVSSSALALIIPPLLEVTTYYGEGISPL--TITKDALIS 440

  Fly   432 LIGLIFGIVGCTVALMQLIR 451
            ::|.:..:||...:|.:||:
  Rat   441 ILGFVGFVVGTYESLWELIQ 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	103/378 (27%)
Slc36a1	NP_569099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		5/29 (17%)
Slc36a1	NP_569099.1	SLC5-6-like_sbd	47..452	CDD:382020	114/417 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860