DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and SLC36A2

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_861441.2	Gene:	SLC36A2 / 153201	HGNCID:	18762	Length:	483	Species:	Homo sapiens

Alignment Length:	476	Identity:	118/476 - (24%)
Similarity:	223/476 - (46%)	Gaps:	58/476 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PKSQDQAPNRDDPDLQTEP-----LTIAQSITSFYMYNPYEKRSVEVPLTNCDAFISLLKCVIGT 62
            |:|..:..|:|...|...|     |...:.||.|                  .|.|.|:|..:||
Human    24 PESAKKLENKDSTFLDESPSESAGLKKTKGITVF------------------QALIHLVKGNMGT 70

  Fly    63 GILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGP 127
            |||.:|||.:.:|.:||.:..:::..:..:.:|:|:......|:|...|.:...:.|....|..|
Human    71 GILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEANP 135

  Fly   128 K-WINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEIGDHYIERYN--------------- 176
            . |:.........:.:..|:..|...|.||:||::.|.|::    :|..|
Human   136 NAWLQNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQV----VEAVNSTTNNCYSNETVILT 196

  Fly   177 ----ERYYVLVACLLLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFNGLPNINDREMVTP 237
                .|.|:|.....|:.|.:||.|:.|...::::|..:.....:|:.|:...:|:.:...:|..
Human   197 PTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVAS 261

  Fly   238 PVEWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGI--IGYWRF 300
            ...:..|...|.||..::|.:|.:|..|.:.:.:..:     |::...::::::.|:  :||.||
Human   262 WKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAI-----LSLGMSIVTSLYIGMAALGYLRF 321

  Fly   301 GDNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDYENSEPRGRYRTLIEYV 365
            ||::.|||:||:| :..|.|.:|:...:||..:|.|..:|...::. .:..|....|:...::..
Human   322 GDDIKASISLNLP-NCWLYQSVKLLYIAGILCTYALQFYVPAEIII-PFAISRVSTRWALPLDLS 384

  Fly   366 VRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWKLIRDILL 430
            :||:.:.||..:||.:|.|..:..|.|:.|.:.|.|:.|.|::|...|:.|...|  .:.:|.|:
Human   385 IRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEVTTFYSEGMSPL--TIFKDALI 447

  Fly   431 ILIGLIFGIVGCTVALMQLIR 451
            .::|.:..:||...||.:|::
Human   448 SILGFVGFVVGTYQALDELLK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	95/378 (25%)
SLC36A2	NP_861441.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..46		5/19 (26%)
SLC36A2	NP_861441.2	SLC5-6-like_sbd	52..463	CDD:320982	108/441 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860