DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and SLC32A1

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_542119.1	Gene:	SLC32A1 / 140679	HGNCID:	11018	Length:	525	Species:	Homo sapiens

Alignment Length:	441	Identity:	97/441 - (21%)
Similarity:	180/441 - (40%)	Gaps:	68/441 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LTNCDAFISLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRV 110
            :|..:|..::...:.|..:|.:|.|....|: :|..:.|...::..|:..:|||.:.|
Human   116 ITAWEAGWNVTNAIQGMFVLGLPYAILHGGY-LGLFLIIFAAVVCCYTGKILIACLYE------- 172

  Fly   111 PQVSMPEAVRI--AYEE------GPKWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEI 167
             :....|.||:  :|..      .|::....||.........||    :.|.:|:| ||.|.
Human   173 -ENEDGEVVRVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELV----MTCILYVV-VSGNL--- 228

  Fly   168 GDHYIERYN--------ERYYVLVACLLLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFN 224
                  .||        ::.:.::|..:|||...::.||.:...:|:.....:....|::.|.
Human   229 ------MYNSFPGLPVSQKSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYC-- 285

  Fly   225 GLPNIND--REMVTPPVEWIEF---IAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLF 284
             |....|  .|.|...::..:|   |.|..||.|:...:..:|.:|..|..:..:....::|...
Human   286 -LSRARDWAWEKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACV 349

  Fly   285 ILLSNMFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDY 349
            :   ...|.::.|..:.|.....||.|:|..  :...:.:|:.:...|||||..|..:.|:....
Human   350 L---KGLFALVAYLTWADETKEVITDNLPGS--IRAVVNIFLVAKALLSYPLPFFAAVEVLEKSL 409

  Fly   350 ENSEPR----------GRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCP 404
            .....|          ||.::. ...:|...:..|..:||.||:.|.|..|.|:.:.:.|..|.|
Human   410 FQEGSRAFFPACYSGDGRLKSW-GLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLP 473

  Fly   405 ALIDVFLNYNVGYGRLMW-KLIRDILLILIGLIFGIVGCTVALMQLIRDFQ 454
            :|..:.|.:.    :|:| ::..|:.:.:||.|..:.|...:|..||..::
Human   474 SLFHLRLLWR----KLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	84/387 (22%)
SLC32A1	NP_542119.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..107
SLC32A1	NP_542119.1	Aa_trans	115..512	CDD:279788	94/431 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740