DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polyph and slc38a5a

DIOPT Version :9

Sequence 1:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	XP_001344749.1	Gene:	slc38a5a / 100005797	ZFINID:	ZDB-GENE-081105-92	Length:	491	Species:	Danio rerio

Alignment Length:	502	Identity:	92/502 - (18%)
Similarity:	187/502 - (37%)	Gaps:	98/502 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PLTIAQSITSF----------YMYNPYEKRSVEVPLTNCD-------AFISLLKCVIGTGILAMP 68
            |:.:.:..|.|          ...:......:|...|:.:       :..:|...::|:|||.:.
Zfish    15 PMNLEKEFTGFDALENMAEGDQFLSSKSNGKIETQFTDFEGKTSFGMSIFNLSNAIMGSGILGLA 79

  Fly    69 LAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGPKWINCF 133
            .|...:|.::...:.|.:.:|.:||||||:         |....|.:....::.|       ..|
Zfish    80 YAMANTGIILFVFLLITIALLSSYSIHLLL---------RSAGVVGIRAYEQLGY-------RAF 128

  Fly   134 GRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEI-----------GDHYIE-RYNERYYVLVACL 186
            |.....:..|::........:.||..|......:           |..|:: ||   ..::|:..
Zfish   129 GTPGKVVAGCIITLHNIGAMSSYLFIVKIELPHVIEGLTGLPDNSGHWYVDGRY---LIIIVSVC 190

  Fly   187 LLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFNGLPN--------------INDREMVTP 237
            ::.||.:::||.|   |...|.|.|......::..::..|.|              .::..|::.
Zfish   191 VIFPLALMKRLGY---LGYTSGFSLSCMVFFLISVIYKCLSNSGIDSESNQNEKCTFSNASMISS 252

  Fly   238 PVEWIEF---------------------IAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLA 281
            ..|..|.                     |.|.||:......:|.:...:.:| |...:..|.|::
Zfish   253 TTEINEINSTTEICEAKLLTINPQTAFTIPIIAFAFVCHPEVLPIYTELKNP-SKKQMQKVANIS 316

  Fly   282 VLFILLSNMFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGF----VVI 342
            :|.:.:..:...|.||..|..||.:.:.....:::||...:::.:...:.|:.|:..|    .|:
Zfish   317 ILAMFVMYLLTAIFGYLTFFANVDSELLKMYNKNDILMLCVRLAVLVAVTLTVPVVLFPIRRAVL 381

  Fly   343 TVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALI 407
            .::|       |...:..:...::.:..||....:.|.|||:..:....||.|..:|..:.|.:.
Zfish   382 QLLF-------PEKPFSWVRHIIIAMCLLFAVNLLVIFVPNIRDIFGFIGATSAPSLIFILPGIF 439

  Fly   408 DVFLNYNVGYGRLMWKLIRDILLILIGLIFGIVGCTVALMQLIRDFQ 454
            .:::.............|..||.:.:|.||.|:..|..:::.:...|
Zfish   440 YIYIVPEEQEPLKSRPKILAILFVTLGFIFMIMSITFIIIEWVNGKQ 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	78/414 (19%)
slc38a5a	XP_001344749.1	SdaC	55..479	CDD:223884	86/453 (19%)
slc38a5a	XP_001344749.1	SLC5-6-like_sbd	55..479	CDD:294310	86/453 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840