Protein Alignment CG12942 and ZNF208

DIOPT Version :10

• Sequence 1: NP_610628.2
• Gene: CG12942 / 36158
• FlyBaseID: FBgn0033569
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_009084.2
• Gene: ZNF208 / 7757
• HGNCID: 12999
• Length: 1280
• Species: Homo sapiens
• Alignment Length: 389
• Identity: 93/389 - (23%)
• Similarity: 162/389 - (41%)
• Gaps: 59/389 - (15%)

  Fly   298 TGNIPILKCNIC----QYTHTDAEQLKIHY-----------KSIHKISMMEDDIIGLNKNQNFKC 347
            ||..| .||..|    .::....|..|||.           |.....|::....:..|..:.:||
Human   420 TGEKP-YKCEECGKAFNWSSNLMEHKKIHTGETPYKCEECGKGFSMFSILTKHKVIHNGEKPYKC 483

  Fly   348 RPCNS--------YETKDRSE---MQKHLIDHHKIDGDFEMYCYMQANCPACDRIFKDQRSARKH 401
            ..|:.        |:.::..:   ...:|::|.:|....:.|     .|..|.:.|.......||
Human   484 EECDKATHAGEKPYKCEECGKAFNWSSNLMEHKRIHTGEKPY-----KCEECGKSFSTFSILTKH 543

  Fly   402 YTRVHTPVQIAVSPTESYACTACDKVFNQKASLHSHQRFCQVKDVVHCSFCDQQFNSMRKYELHL 466
            .. :||       ..:.|.|..|.|.:...::|..|::...|:....|..|.:.||.......|
Human   544 KV-IHT-------GEKPYKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEECGKAFNQSAILIKH- 599

  Fly   467 QQLHAVETVHECEICRRSFKSAETLTMHRKRHS-ERHYQCGKCSLNYVNSAELRVHYERAHVNEE 530
            :::|..|..::||.|.::|....|||.|:..|: |:.|:|.:|...::..:.|..| :..|..|:
Human   600 KRIHTGEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKECGKTFIKVSTLTTH-KAIHAGEK 663

  Fly   531 PVSCLTCGNQFQNMTLLREHEQRSHQKSKVWRCEVC----NFETKTRWRRRQHQYEHMDYPYKCQ 591
            |..|..||..|...::|.:|:. .|...|.::||.|    |:.:.....:|.|..|.   ||||:
Human   664 PYKCKECGKAFSKFSILTKHKV-IHTGEKPYKCEECGKAFNWSSNLMEHKRIHTGEK---PYKCE 724

  Fly   592 KCTSEFADRSKFRQHSKKVHGIE--LSDEQLAEMFREKKGYTNRHDAFNKSINSLEIPGLTEDC 653
            :|...|:..|...:| |.:|..|  ...|:..:.::.....     :::|.|:::|.|...|:|
Human   725 ECGKSFSTFSVLTKH-KVIHTGEKPYKCEECGKAYKWSSTL-----SYHKKIHTVEKPYKCEEC 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12942	NP_610628.2	zf-AD	21..100	CDD:462262
		C2H2 Zn finger	385..406	CDD:275368	5/20 (25%)
		C2H2 Zn finger	421..470	CDD:275368	11/48 (23%)
		C2H2 Zn finger	449..466	CDD:275371	4/16 (25%)
		C2H2 Zn finger	478..498	CDD:275368	8/19 (42%)
		C2H2 Zn finger	505..526	CDD:275368	4/20 (20%)
		C2H2 Zn finger	534..555	CDD:275368	6/20 (30%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381	45/213 (21%)
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368	4/19 (21%)
		C2H2 Zn finger	455..475	CDD:275368	2/19 (11%)
		C2H2 Zn finger	499..519	CDD:275368	2/19 (11%)
		C2H2 Zn finger	527..547	CDD:275368	5/20 (25%)
		C2H2 Zn finger	555..575	CDD:275368	5/19 (26%)
		C2H2 Zn finger	583..603	CDD:275368	5/20 (25%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	639..659	CDD:275368	4/20 (20%)
		C2H2 Zn finger	667..687	CDD:275368	6/20 (30%)
		COG5048	691..1133	CDD:227381	26/101 (26%)
		C2H2 Zn finger	695..715	CDD:275368	5/19 (26%)
		C2H2 Zn finger	723..743	CDD:275368	6/20 (30%)
		C2H2 Zn finger	751..771	CDD:275368	2/24 (8%)
		C2H2 Zn finger	779..799	CDD:275368	2/4 (50%)
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
		C2H2 Zn finger	891..911	CDD:275368
		C2H2 Zn finger	919..939	CDD:275368
		C2H2 Zn finger	947..967	CDD:275368
		C2H2 Zn finger	976..995	CDD:275368
		C2H2 Zn finger	1003..1023	CDD:275368
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1059..1079	CDD:275368
		C2H2 Zn finger	1087..1107	CDD:275368
		C2H2 Zn finger	1115..1135	CDD:275368
		SFP1	<1137..1217	CDD:227516
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		SFP1	<1193..1273	CDD:227516
		C2H2 Zn finger	1199..1219	CDD:275368
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368