DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12942 and ZNF175

DIOPT Version :10

Sequence 1:NP_610628.2 Gene:CG12942 / 36158 FlyBaseID:FBgn0033569 Length:686 Species:Drosophila melanogaster
Sequence 2:NP_009078.1 Gene:ZNF175 / 7728 HGNCID:12964 Length:711 Species:Homo sapiens


Alignment Length:723 Identity:159/723 - (21%)
Similarity:279/723 - (38%) Gaps:136/723 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PALLAMNKLNKGSKCRACLSVDRKTVQLNAEVPNLQKTRTYAQSLKQCTNLDL--RVISPGGYLW 70
            |.:|...|  :...|.|.:|.:..||..:.|  ..|:.....:.|.:...|:|  .:.:.|.::.
Human    11 PQVLGPEK--QDGSCEASVSFEDVTVDFSRE--EWQQLDPAQRCLYRDVMLELYSHLFAVGYHIP 71

  Fly    71 PMQICVRCCRALEVAMHFVEMALESNLKLQAEAKSVKLPSPTGELKRKASNETIPWNQFSQE--- 132
            ..::..|..:..|..   ||.|..|:.:.|.....:::|..  |:.:|||.:.....:|:::   
Human    72 NPEVIFRMLKEKEPR---VEEAEVSHQRCQEREFGLEIPQK--EISKKASFQKDMVGEFTRDGSW 131

  Fly   133 ---FEQF----------VEGYEGPIEENVLYMRGTKVPRLDVDAS----------------SSSE 168
               .|:.          .:....|:..:..:.:.|    |:.:::                :||:
Human   132 CSILEELRLDADRTKKDEQNQIQPMSHSAFFNKKT----LNTESNCEYKDPGKMIRTRPHLASSQ 192

  Fly   169 TAPKEDEVILFDVKYDTNDLEEEDENDGSDAKNNETFFENSITPGE--SVMVVSVAEKAVENNNN 231
            ..|:  :..||......| ||...:|:.:|.:.    .::.:..|:  |........|.:.....
Human   193 KQPQ--KCCLFTESLKLN-LEVNGQNESNDTEQ----LDDVVGSGQLFSHSSSDACSKNIHTGET 250

  Fly   232 YNFNNKNGDVTDEECDLIQRALEMTLNDDGCSQ-----SPKNEASNETQLKSNGI--------EV 283
            :...|:...|...:..|.|..:......||||:     :.|:....:.::.|.|.        :.
Human   251 FCKGNQCRKVCGHKQSLKQHQIHTQKKPDGCSECGGSFTQKSHLFAQQRIHSVGNLHECGKCGKA 315

  Fly   284 SSPLFIKLAT-TSSTTGNIPILKCNICQYTHTDAEQLKIHYKS--------IHKISMMEDDIIGL 339
            ..|. :||:. .:..||:||.: |..|........:|..|.|:        .|........::.|
Human   316 FMPQ-LKLSVYLTDHTGDIPCI-CKECGKVFIQRSELLTHQKTHTRKKPYKCHDCGKAFFQMLSL 378

  Fly   340 NKNQN-------FKCRPCNSYETKDRSEMQKHLIDHHKIDGDFEMYCYMQANCPACDRIFKDQRS 397
            .::|.       ::|..|....:::.:     ||.|.||......|.     |..|.:.| .|:|
Human   379 FRHQRTHSREKLYECSECGKGFSQNST-----LIIHQKIHTGERQYA-----CSECGKAF-TQKS 432

  Fly   398 ARKHYTRVHTPVQIAVSPTESYACTACDKVFNQKASLHSHQRFCQVKDVVHCSFCDQQFNSMRKY 462
            ....:.|:|       |..:||.|..|.:.|.|||.|..|||....:....|..|.:.|.|..:.
Human   433 TLSLHQRIH-------SGQKSYVCIECGQAFIQKAHLIVHQRSHTGEKPYQCHNCGKSFISKSQL 490

  Fly   463 ELHLQQLHAVETVHECEICRRSFKSAETLTMHRKRHS-ERHYQCGKCSLNYVNSAELRVHYERAH 526
            ::| .::|..|..:||..|.::|.....|.:|:|.|: |||:.|.:|...:...:.|.:| :|.|
Human   491 DIH-HRIHTGEKPYECSDCGKTFTQKSHLNIHQKIHTGERHHVCSECGKAFNQKSILSMH-QRIH 553

  Fly   527 VNEEPVSCLTCGNQFQNMTLLREHEQRSHQKSKVWRCEVCNFETKTRWRRRQHQYEH-MDYPYKC 590
            ..|:|..|..||..|.:.:..:|| ||.|...|.:.|..|......|....:||..| .:.|:.|
Human   554 TGEKPYKCSECGKAFTSKSQFKEH-QRIHTGEKPYVCTECGKAFNGRSNFHKHQITHTRERPFVC 617

  Fly   591 QKCTSEFADRSKFRQHSKKVHGIELSDEQL--AEMFREK----------------------KGYT 631
            .||...|..:|:...| ::.|..|...|.|  .:.|.:|                      |.:.
Human   618 YKCGKAFVQKSELITH-QRTHMGEKPYECLDCGKSFSKKPQLKVHQRIHTGERPYVCSECGKAFN 681

  Fly   632 NRHDAFNK 639
            ||.: |||
Human   682 NRSN-FNK 688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12942NP_610628.2 zf-AD 21..100 CDD:462262 17/80 (21%)
C2H2 Zn finger 385..406 CDD:275368 6/20 (30%)
C2H2 Zn finger 421..470 CDD:275368 15/48 (31%)
C2H2 Zn finger 449..466 CDD:275371 4/16 (25%)
C2H2 Zn finger 478..498 CDD:275368 6/19 (32%)
C2H2 Zn finger 505..526 CDD:275368 5/20 (25%)
C2H2 Zn finger 534..555 CDD:275368 8/20 (40%)
ZNF175NP_009078.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 3/11 (27%)
KRAB 27..85 CDD:214630 10/59 (17%)
C2H2 Zn finger 230..246 CDD:275368 3/15 (20%)
C2H2 Zn finger 255..273 CDD:275368 4/17 (24%)
COG5048 275..689 CDD:227381 111/439 (25%)
C2H2 Zn finger 281..300 CDD:275368 3/18 (17%)
C2H2 Zn finger 309..329 CDD:275368 3/20 (15%)
C2H2 Zn finger 337..357 CDD:275368 5/19 (26%)
Nuclear localization signal. /evidence=ECO:0000255 359..362 0/2 (0%)
C2H2 Zn finger 365..385 CDD:275368 3/19 (16%)
C2H2 Zn finger 393..413 CDD:275368 6/24 (25%)
C2H2 Zn finger 421..441 CDD:275368 6/20 (30%)
C2H2 Zn finger 449..469 CDD:275368 10/19 (53%)
C2H2 Zn finger 477..497 CDD:275368 5/20 (25%)
C2H2 Zn finger 505..525 CDD:275368 6/19 (32%)
C2H2 Zn finger 533..553 CDD:275368 5/20 (25%)
C2H2 Zn finger 561..581 CDD:275368 8/20 (40%)
C2H2 Zn finger 589..609 CDD:275368 5/19 (26%)
C2H2 Zn finger 617..637 CDD:275368 6/20 (30%)
C2H2 Zn finger 645..665 CDD:275368 3/19 (16%)
C2H2 Zn finger 673..693 CDD:275368 6/17 (35%)

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