Protein Alignment CG12942 and ZNF808

DIOPT Version :10

• Sequence 1: NP_610628.2
• Gene: CG12942 / 36158
• FlyBaseID: FBgn0033569
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001034975.2
• Gene: ZNF808 / 388558
• HGNCID: 33230
• Length: 903
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 138/603 - (22%)
• Similarity: 215/603 - (35%)
• Gaps: 156/603 - (25%)

  Fly    78 CCRALEVAMHFVEMALESNLKLQAEAKSVKLPSPTGEL----KRKASNETIPWNQFSQEFEQFVE 138
            |.:.:|..:|.:|...:.:.:...||.:.|:...||..    .|.|.|:
Human   102 CFQEIEKEIHNIEFQCQEDERNGHEAPTTKIKKLTGSTDQHDHRHAGNK---------------- 150

  Fly   139 GYEGPIEENVLYMRGTKVPRLDVDASSSSETAPKEDEVILFDVKYDTNDLEEEDENDGSDAKNNE 203
                ||::.:              .||.....|   |:.:|.:|   .::..:.|...|||.:..
Human   151 ----PIKDQL--------------GSSFYSHLP---ELHIFQIK---GEIANQLEKSTSDASSVS 191

  Fly   204 TFFENSITPGESVMVVSVAEKAVENNNNYNFNNKNGDVTDEECDLIQRALEMTLNDDG----CSQ 264
            |....|..|            .:..:|||..|..|..:..::.::..|......|:.|    ||.
Human   192 TSQRISCRP------------QIHISNNYGNNPLNSSLLPQKQEVHMREKSFPCNESGKAFNCSS 244

  Fly   265 SPKNEASNETQLKSNGIEVSSPLF-----------------------------IKLATTSS---T 297
            ..:.........|....:|...||                             .|.:.|..   .
Human   245 LLRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTGEKPYKCKECGKSFSYKSSLTCHHRLH 309

  Fly   298 TGNIPILKCNICQYTHTDAEQLKIHYKSIHKISMMEDDIIGLNKNQNFKCRPCNSYETKDRSEMQ 362
            ||..| .|||.|.........|.|| |:||            ...:.:||..|..     ....|
Human   310 TGVKP-YKCNECGKVFRQNSALVIH-KAIH------------TGEKPYKCNECGK-----AFNQQ 355

  Fly   363 KHLIDHHKI------------DGDFEMYCYMQAN------------CPACDRIFKDQRSARKHYT 403
            .||..|.::            :..|..:.|: ||            |..|.:.|..|.|..:|:.
Human   356 SHLSRHQRLHTGVKPYKCKICEKAFACHSYL-ANHTRIHSGEKTYKCNECGKAFNHQSSLARHHI 419

  Fly   404 RVHTPVQIAVSPTESYACTACDKVFNQKASLHSHQRFCQVKDVVHCSFCDQQFNSMRKYELHLQQ 468
             :||       ..:.|.|..|||||:||::|..|:|....:....|..||..|....:...| ::
Human   420 -LHT-------GEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKVCDTAFTCNSQLARH-RR 475

  Fly   469 LHAVETVHECEICRRSFKSAETLTMHRKRHS-ERHYQCGKCSLNYVNSAELRVHYERAHVNEEPV 532
            :|..|..::|..||::|....:|..||:.|| |:.|:|.:|...:.:.|.| |::.|.|..|:..
Human   476 IHTGEKTYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASL-VYHRRLHTLEKSY 539

  Fly   533 SCLTCGNQFQNMTLLREHEQRSHQKSKVWRCEVC----NFETKTRWRRRQHQYEHMDYPYKCQKC 593
            .|..|...|...::|..| .|.|...|.::|..|    |.::.....||.|..|.   ||||:.|
Human   540 KCTVCNKVFMRNSVLAVH-TRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEK---PYKCEAC 600

  Fly   594 TSEFADRSKFRQHSKKVH 611
            ...|..:|....| |::|
Human   601 DKVFGQKSALESH-KRIH 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12942	NP_610628.2	zf-AD	21..100	CDD:462262	4/21 (19%)
		C2H2 Zn finger	385..406	CDD:275368	6/20 (30%)
		C2H2 Zn finger	421..470	CDD:275368	16/48 (33%)
		C2H2 Zn finger	449..466	CDD:275371	4/16 (25%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..526	CDD:275368	6/20 (30%)
		C2H2 Zn finger	534..555	CDD:275368	6/20 (30%)
ZNF808	NP_001034975.2	KRAB	24..60	CDD:460171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..154		10/52 (19%)
		COG5048	206..585	CDD:227381	97/409 (24%)
		C2H2 Zn finger	233..253	CDD:275368	4/19 (21%)
		C2H2 Zn finger	261..281	CDD:275368	3/19 (16%)
		C2H2 Zn finger	289..309	CDD:275368	2/19 (11%)
		C2H2 Zn finger	317..337	CDD:275368	7/20 (35%)
		C2H2 Zn finger	345..365	CDD:275368	6/24 (25%)
		C2H2 Zn finger	373..393	CDD:275368	4/20 (20%)
		COG5048	397..839	CDD:227381	71/236 (30%)
		C2H2 Zn finger	401..421	CDD:275368	6/20 (30%)
		C2H2 Zn finger	429..449	CDD:275368	11/19 (58%)
		C2H2 Zn finger	457..477	CDD:275368	5/20 (25%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		C2H2 Zn finger	513..533	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..561	CDD:275368	6/20 (30%)
		C2H2 Zn finger	569..589	CDD:275368	5/19 (26%)
		C2H2 Zn finger	597..617	CDD:275368	6/20 (30%)
		C2H2 Zn finger	625..645	CDD:275368
		C2H2 Zn finger	653..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		C2H2 Zn finger	709..729	CDD:275368
		C2H2 Zn finger	737..757	CDD:275368
		C2H2 Zn finger	765..785	CDD:275368
		C2H2 Zn finger	793..813	CDD:275368
		C2H2 Zn finger	821..841	CDD:275368
		zf-H2C2_2	833..858	CDD:463886
		C2H2 Zn finger	849..869	CDD:275368
		zf-H2C2_2	861..885	CDD:463886
		C2H2 Zn finger	877..897	CDD:275368