Protein Alignment CG12942 and Zfy2

DIOPT Version :10

• Sequence 1: NP_610628.2
• Gene: CG12942 / 36158
• FlyBaseID: FBgn0033569
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_033597.2
• Gene: Zfy2 / 22768
• MGIID: 99213
• Length: 777
• Species: Mus musculus
• Alignment Length: 614
• Identity: 131/614 - (21%)
• Similarity: 229/614 - (37%)
• Gaps: 148/614 - (24%)

  Fly    90 EMALESNLKLQAEAKSVKLPSPTGELKR----KASNETIPWNQFSQEFEQFVE-GYEGPIEENVL 149
            |.:.|..:..::|..|.||...:.|:.:    ||.:|.....:..|..|...: |.|..:.:.
Mouse   214 EGSSEVTMNAESETDSSKLDEASPEVIKVCILKADSEVDDVGETIQAVESETDNGNEAEVTDQ-- 276

  Fly   150 YMRGTKVPRLDVDASSSSETAPKED-EVILFD-----VKYDTNDLEEEDENDGSDAKNNETFFEN 208
             .....|||:::...:|.....:|| :||:.|     ...||.  |.|.:.|.|:.|
Mouse   277 -RTSIHVPRVNIYMLASDSQKEEEDTKVIVGDEDAGGTAADTP--EHEQQMDVSEIK-------- 330

  Fly   209 SITPGESVMVVSVAEKAVENNNNYNFNNKNGDVTDEECDLIQRALEMTLNDD--GCSQSPKNEAS 271
                   ...:.:|..|..:||:.....:|.           .|..|..:|:  |..:.||.::.
Mouse   331 -------AAFLPIAWTAAYDNNSDEIEVQNA-----------TASAMLHHDESGGLDRVPKQKSK 377

  Fly   272 NETQLKSNGIEVSSPLFIKLATTSSTTGNIPIL----------------------------KCNI 308
            .:.:.:|.  :..|.:|:  |....|....|.:                            .|..
Mouse   378 KKKRPESK--QYQSAIFV--APDGQTLRVYPCMFCGKKFKTKRFLKRHIKNHPEYLANKKYHCTE 438

  Fly   309 CQYTHTDAEQLKIHYKSIHKISMMEDDII-------------------GLNKNQNFKCRPCNSYE 354
            |.|:......|..|.:| ||:::..:...                   |:||  ..||:.|: ||
Mouse   439 CDYSTNKKISLHNHMES-HKLTIKTEKTTECDDCRKNLSHAGTMHTEKGVNK--TCKCKFCD-YE 499

  Fly   355 TKDRSEMQKHLIDHHKIDGDFEMYCYMQANCPACDRIFKDQRSARKHYTRVHTPVQIAVSPTESY 419
            |.:::.:..||:..|:     :.:.::   |..|.:.|:...:.:|| .||||       ..:.|
Mouse   500 TAEQTLLNHHLLVVHR-----KKFPHI---CGECGKGFRHPSALKKH-IRVHT-------GEKPY 548

  Fly   420 ACTACDKVFNQKASLHSHQR-----------------FCQVKD-----VVH-------CSFCDQQ 455
            .|..|:......::|.:|.:                 |...|:     |:|       ||.|:.:
Mouse   549 ECQYCEYKSADSSNLKTHIKSKHSKEIPLKCGICLLTFSDTKEAQQHAVLHQESRTHQCSHCNHK 613

  Fly   456 FNSMRKYELHLQQLHAVETVHECEICRRSFKSAETLTMHRKRH-SERHYQCGKCSLNYVNSAELR 519
            .::....:.|:..:|.....|:|::|.:.|.....|..|...| |::.:||..|.....:...|.
Mouse   614 SSNSSDLKRHIISVHTKAYPHKCDMCSKGFHRPSELKKHVATHKSKKMHQCRHCDFKSPDPFLLS 678

  Fly   520 VHYERAHVNEEPVSCLTCGNQFQNMTLLREHEQRSHQKSKVWRCEVCNFETK--TRWRRRQHQYE 582
            .|...||....|..|..|..:||....|:.| .::|...||::||.|.:.||  :.::|......
Mouse   679 HHILSAHTKNVPFKCKRCKKEFQQQCELQTH-MKTHSSRKVYQCEYCEYSTKDASGFKRHVISIH 742

  Fly   583 HMDYPYKCQKCTSEFADRSKFRQHSKKVH 611
            ..|||::|..|...|...|:..||..:.|
Mouse   743 TKDYPHRCDFCKKGFRRPSEKNQHIMRHH 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12942	NP_610628.2	zf-AD	21..100	CDD:462262	2/9 (22%)
		C2H2 Zn finger	385..406	CDD:275368	6/20 (30%)
		C2H2 Zn finger	421..470	CDD:275368	12/77 (16%)
		C2H2 Zn finger	449..466	CDD:275371	3/16 (19%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	505..526	CDD:275368	4/20 (20%)
		C2H2 Zn finger	534..555	CDD:275368	6/20 (30%)
Zfy2	NP_033597.2	Zfx_Zfy_act	68..388	CDD:461400	42/206 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..234		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..389		5/29 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		2/9 (22%)
		C2H2 Zn finger	405..425	CDD:275370	0/19 (0%)
		C2H2 Zn finger	436..456	CDD:275368	6/20 (30%)
		COG5048	<442..681	CDD:227381	52/258 (20%)
		C2H2 Zn finger	493..514	CDD:275368	7/21 (33%)
		C2H2 Zn finger	522..542	CDD:275368	6/20 (30%)
		C2H2 Zn finger	550..571	CDD:275368	4/20 (20%)
		C2H2 Zn finger	579..599	CDD:275368	3/19 (16%)
		C2H2 Zn finger	607..628	CDD:275368	4/20 (20%)
		C2H2 Zn finger	636..685	CDD:275368	12/48 (25%)
		C2H2 Zn finger	693..713	CDD:275368	6/20 (30%)
		zf-H2C2_2	705..729	CDD:463886	8/24 (33%)
		C2H2 Zn finger	721..742	CDD:275368	6/20 (30%)
		C2H2 Zn finger	750..770	CDD:275368	6/19 (32%)