Protein Alignment CG12942 and ZNF791

DIOPT Version :10

• Sequence 1: NP_610628.2
• Gene: CG12942 / 36158
• FlyBaseID: FBgn0033569
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_699189.2
• Gene: ZNF791 / 163049
• HGNCID: 26895
• Length: 576
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 123/595 - (20%)
• Similarity: 219/595 - (36%)
• Gaps: 171/595 - (28%)

  Fly   160 DVDASSSSE----TAPKEDEVILFDV-------------KYDTNDLEEEDENDGSDAKNNETFFE 207
            ||..|.|.|    .||.:.: :..||             |::..::|::.:|.|.:.:::
Human     8 DVSVSFSQEEWALLAPSQKK-LYRDVMQETFKNLASIGEKWEDPNVEDQHKNQGRNLRSH----- 66

  Fly   208 NSITPGESVMVVSVAEKAVEN-NNNYNFNNKNGDVTDEECDLIQRALEMTLNDDGCSQSPKNEAS 271
                .||.:.......:..|| :.|.:...|...|...||.:..:|. |.|:  ..::..::...
Human    67 ----TGERLCEGKEGSQCAENFSPNLSVTKKTAGVKPYECTICGKAF-MRLS--SLTRHMRSHTG 124

  Fly   272 NETQLKSNGIEVSSPLFIKLAT----TSSTTGNIPILKCNIC-------------QYTH------ 313
            .|...|....:.....|..|.:    ..|.||..| .||..|             :.||
Human   125 YELFEKPYKCKECEKAFSYLKSFQRHERSHTGEKP-YKCKQCGKTFIYHQPFQRHERTHIGEKPY 188

  Fly   314 ---------TDAEQLKIHYKSIHKISMMEDDIIGLNKNQNFKCRPC-------NSYETKDRS--- 359
                     :.:..|::| :.||            ...:.::|:.|       :|....:|:
Human   189 ECKQCGKALSCSSSLRVH-ERIH------------TGEKPYECKQCGKAFSCSSSIRVHERTHTG 240

  Fly   360 -------EMQKHLIDH-----HKI--DGDFEMYC-----------YMQAN-----------CPAC 388
                   |..|..|.|     |.|  :||....|           :::.:           |..|
Human   241 EKPYACKECGKAFISHTSVLTHMITHNGDRPYKCKECGKAFIFPSFLRVHERIHTGEKPYKCKQC 305

  Fly   389 DRIFKDQRSARKHYTRVHTPVQIAVSPTESYACTACDKVFNQKASLHSHQRFCQVKDVVHCSFCD 453
            .:.|:...|.:.| .|:||       ..:.|.|..|.|.|:.:.:...|.|....:....|..|.
Human   306 GKAFRCSTSIQIH-ERIHT-------GEKPYKCKECGKSFSARPAFRVHVRVHTGEKPYKCKECG 362

  Fly   454 QQFNSMRKYELHLQQLHAVETVHECEICRRSFKSAETLTMHRKRHS-ERHYQCGKCSLNYVNSAE 517
            :.|:.:..:.:| ::.|..|..:||:.|.::|.....|.:|::.|: |:.|:|.:|:..:::...
Human   363 KAFSRISYFRIH-ERTHTGEKPYECKKCGKTFNYPLDLKIHKRNHTGEKPYECKECAKTFISLEN 426

  Fly   518 LRVH---------------------------YERAHVNEEPVSCLTCGNQFQNMTLLREHEQRSH 555
            .|.|                           :||.|..|:|..|..||..|...:.:|.| :|:|
Human   427 FRRHMITHTGDGPYKCRDCGKVFIFPSALRTHERTHTGEKPYECKQCGKAFSCSSYIRIH-KRTH 490

  Fly   556 QKSKVWRCEVCN----FETKTRWRRRQHQYEHMDYPYKCQKCTSEFADRSKFRQHSKKVHGIE-- 614
            ...|.:.|:.|.    :.|..:...|.|..|.   ||||::|...|:..|.|::|: ::|..|
Human   491 TGEKPYECKECGKAFIYPTSFQGHMRMHTGEK---PYKCKECGKAFSLHSSFQRHT-RIHNYEKP 551

  Fly   615 LSDEQLAEMF 624
            |..:|..:.|
Human   552 LECKQCGKAF 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12942	NP_610628.2	zf-AD	21..100	CDD:462262
		C2H2 Zn finger	385..406	CDD:275368	6/20 (30%)
		C2H2 Zn finger	421..470	CDD:275368	10/48 (21%)
		C2H2 Zn finger	449..466	CDD:275371	3/16 (19%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	505..526	CDD:275368	6/47 (13%)
		C2H2 Zn finger	534..555	CDD:275368	7/20 (35%)
ZNF791	NP_699189.2	KRAB	3..44	CDD:460171	9/36 (25%)
		COG5048	98..573	CDD:227381	103/495 (21%)
		C2H2 Zn finger	102..122	CDD:275368	4/22 (18%)
		C2H2 Zn finger	134..154	CDD:275368	2/19 (11%)
		C2H2 Zn finger	162..182	CDD:275368	2/19 (11%)
		C2H2 Zn finger	190..210	CDD:275368	2/20 (10%)
		C2H2 Zn finger	218..238	CDD:275368	4/19 (21%)
		C2H2 Zn finger	246..266	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	1/19 (5%)
		C2H2 Zn finger	302..322	CDD:275368	6/20 (30%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	358..378	CDD:275368	4/20 (20%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		C2H2 Zn finger	414..434	CDD:275368	4/19 (21%)
		C2H2 Zn finger	442..462	CDD:275368	2/19 (11%)
		C2H2 Zn finger	470..490	CDD:275368	7/20 (35%)
		C2H2 Zn finger	498..518	CDD:275368	4/19 (21%)
		C2H2 Zn finger	526..546	CDD:275368	6/20 (30%)
		C2H2 Zn finger	554..574	CDD:275368	2/8 (25%)