DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cag and JRK

DIOPT Version :9

Sequence 1:	NP_001260876.1	Gene:	cag / 36157	FlyBaseID:	FBgn0017414	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	NP_003715.3	Gene:	JRK / 8629	HGNCID:	6199	Length:	568	Species:	Homo sapiens

Alignment Length:	179	Identity:	47/179 - (26%)
Similarity:	87/179 - (48%)	Gaps:	18/179 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GRVRKPRTSLTLEEKMEVIQSQERNKLSVRDLAKRFNIGKTQAADILKHKQSIKEGLLSGEL-KL 67
            |..|| |..|||:||:::....|:.: |.:.|.:.:|:|.:...||..||..:.....|.:. |.
Human    12 GEKRK-RVVLTLKEKIDICTRLEKGE-SRKALMQEYNVGMSTLYDIRAHKAQLLRFFASSDSNKA 74

  Fly    68 NQMRRNPLSQRGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELGHSNFSA-SSGWLEKW 131
            .:.||...:.:...:|.:.::||...|:|.:|:||.|:.:|||....::..:.... |.|||.::
Human    75 LEQRRTLHTPKLEHLDRVLYEWFLGKRSEGVPVSGPMLIEKAKDFYEQMQLTEPCVFSGGWLWRF 139

  Fly   132 RKRHNVRYND------TGDSLDLQEFEAIL--------VKSEPISNKDD 166
            :.||.::..|      :.|....::|.|..        :.:|.:.|.|:
Human   140 KARHGIKKLDASSEKQSADHQAAEQFCAFFRSLAAEHGLSAEQVYNADE 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cag	NP_001260876.1	CENP-B_N	7..60	CDD:282122	17/52 (33%)
cag	NP_001260876.1	CENPB	78..141	CDD:197828	18/63 (29%)
JRK	NP_003715.3	CENP-B_N	14..66	CDD:282122	17/53 (32%)
		CENPB	83..147	CDD:197828	18/63 (29%)
		DDE_1	213..382	CDD:281213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343623at2759
OrthoFinder	1	1.000	-	-		FOG0000365
OrthoInspector	1	1.000	-	-		otm40429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820