DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cag and POGK

DIOPT Version :9

Sequence 1:	NP_001260876.1	Gene:	cag / 36157	FlyBaseID:	FBgn0017414	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	NP_060012.3	Gene:	POGK / 57645	HGNCID:	18800	Length:	609	Species:	Homo sapiens

Alignment Length:	195	Identity:	38/195 - (19%)
Similarity:	79/195 - (40%)	Gaps:	39/195 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RKPRTSLTLEEKMEVIQ-SQERNKLSVRDLAKRFNIGKTQAADILKHKQSIKEGLLSGELKLNQM 70
            |..|.|.....|:.|:: ::..|....   ||:|.:.:....|..|.|..::..        :.|
Human   194 RGMRRSYDAGFKLMVVEYAESTNNCQA---AKQFGVLEKNVRDWRKVKPQLQNA--------HAM 247

  Fly    71 R---RNPLSQRGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELG--HSNFSASSGWLEK 130
            |   |.|.:.|.|.:|:...::...::.:..||:.|.::.||.::|.|:.  ...|.||.||..:
Human   248 RRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRR 312

  Fly   131 WRKRHNVRYNDTGDSLDLQEFEAILVKSEPISNKDDCDEPYPVTLIEPIYSTEEAMMQLARLKEF 195
            ..:|:::                      .:.:|....:..|..|.|.:.:.:.:::.|.|..::
Human   313 MMRRYDL----------------------SLRHKVPVPQHLPEDLTEKLVTYQRSVLALRRAHDY 355

Fly 196 195
Human 356 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cag	NP_001260876.1	CENP-B_N	7..60	CDD:282122	12/53 (23%)
cag	NP_001260876.1	CENPB	78..141	CDD:197828	16/64 (25%)
POGK	NP_060012.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		KRAB	49..107	CDD:214630
		KRAB_A-box	49..86	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..127
		BrkDBD	195..247	CDD:286662	11/62 (18%)
		CENPB	256..323	CDD:197828	16/88 (18%)
		DDE_1	395..567	CDD:281213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..609
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343623at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820