DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cag and TIGD4

DIOPT Version :9

Sequence 1:	NP_001260876.1	Gene:	cag / 36157	FlyBaseID:	FBgn0017414	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	NP_663772.1	Gene:	TIGD4 / 201798	HGNCID:	18335	Length:	512	Species:	Homo sapiens

Alignment Length:	153	Identity:	43/153 - (28%)
Similarity:	81/153 - (52%)	Gaps:	10/153 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KPRTSLTLEEKMEVIQSQERNKLSVRDLAKRFNIGKTQAADILKHKQSIKEGLLSGELKLNQMRR 72
            |.:.||::|||:::|.:.|..|... ::|..:.|.|...:.|:|:|..:.|...|  |:.:..|:
Human    16 KKKKSLSIEEKIDIINAVESGKKKA-EIAAEYGIKKNSLSSIMKNKDKVLEAFES--LRFDPKRK 77

  Fly    73 NPLSQRGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELGHSNFSASSGWLEKWRKRHNV 137
            ...:.....::|....|:...:..|:|::|.|:|.||...|.:|||::|..|:|||::::.|:.:
Human    78 RLRTAFYTDLEEALMRWYRIAQCLNVPVNGPMLRLKANDFAQKLGHNDFKCSNGWLDRFKSRYGL 142

  Fly   138 RYNDTGDSLDLQEFEAILVKSEP 160
            .:.       .|..||..|..:|
Human   143 VFR-------AQPVEATGVPVDP 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cag	NP_001260876.1	CENP-B_N	7..60	CDD:282122	16/51 (31%)
cag	NP_001260876.1	CENPB	78..141	CDD:197828	19/62 (31%)
TIGD4	NP_663772.1	HTH	16..67	CDD:304362	16/51 (31%)
		HTH_Tnp_Tc5	84..143	CDD:281246	19/58 (33%)
		rve	211..375	CDD:304425
		CENP-B_dimeris	427..>504	CDD:286159
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343623at2759
OrthoFinder	1	1.000	-	-		FOG0000365
OrthoInspector	1	1.000	-	-		otm40429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850