DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cag and TIGD1

DIOPT Version :9

Sequence 1:	NP_001260876.1	Gene:	cag / 36157	FlyBaseID:	FBgn0017414	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	NP_663748.1	Gene:	TIGD1 / 200765	HGNCID:	14523	Length:	591	Species:	Homo sapiens

Alignment Length:	226	Identity:	53/226 - (23%)
Similarity:	94/226 - (41%)	Gaps:	56/226 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RKPRTSLTLEEKMEVIQSQERNKLSVRDLAKRFNIGKTQAADILKHKQS-IKEGLLSGELKLNQM 70
            ||.||||||.:|:|:|:..|.. :|..::.:|..:.:...:.::..|:. :||...:..:....:
Human     9 RKSRTSLTLNQKLEMIKLSEEG-MSKAEIGRRLGLLRQTVSQVVNAKEKFLKEVKSATPMNTRMI 72

  Fly    71 R-RNPLSQRGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQL--------AVELGHSNFSASSG 126
            | ||.|.   |.::::...|.....:.|||:|..:::.||..|        .||.....|.||.|
Human    73 RKRNSLI---ADMEKVLVVWIEDQTSRNIPLSQSLIQNKALTLFNSMKAERGVEAAEEKFEASRG 134

  Fly   127 WLEKWRKR---HNVRYNDTGDSLDLQEFEAILVKSEPISNKDDCDEPYPVTLIEPIYSTEEAMMQ 188
            |..::::|   ||::......|.|                            :|...|..||:.:
Human   135 WFMRFKERSHFHNIKAQGEAASAD----------------------------VEAAASYPEALAK 171

  Fly   189 LARLKEFAKDDYASY--QQLISL-ENQWSWK 216
            :.        |...|  ||:.:: |..:.||
Human   172 II--------DEGGYTKQQIFNVDETAFYWK 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cag	NP_001260876.1	CENP-B_N	7..60	CDD:282122	17/53 (32%)
cag	NP_001260876.1	CENPB	78..141	CDD:197828	19/73 (26%)
TIGD1	NP_663748.1	CENP-B_N	9..60	CDD:282122	15/51 (29%)
		CENPB	76..149	CDD:197828	21/75 (28%)
		DDE_1	216..403	CDD:281213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343623at2759
OrthoFinder	1	1.000	-	-		FOG0000365
OrthoInspector	1	1.000	-	-		otm40429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820